Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR

Tsui Chin Huang; Hsin Yi Chang; Cheng Yu Chen; Pei Yi Wu; Hsinyu Lee; Yung Feng Liao; Wen Ming Hsu; Hsuan Cheng Huang; Hsueh Fen Juan

doi:10.1016/j.febslet.2011.10.025

Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR

Tsui Chin Huang, Hsin Yi Chang, Cheng Yu Chen, Pei Yi Wu, Hsinyu Lee, Yung Feng Liao, Wen Ming Hsu, Hsuan Cheng Huang, Hsueh Fen Juan

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Neuroblastoma is the most common extracranial solid tumor in children. We investigate whether miR-124, the abundant neuronal miRNA, plays a pivotal role in neuroblastoma. Knockdown of miR-124 promotes neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis. Further miR-124 is predicted to target aryl hydrocarbon receptor (AHR) which may promote neuroblastoma cell differentiation. We validate that miR-124 may suppress the expression of AHR by targeting its 3′-UTR. These results suggest that miR-124 could serve as a potential therapeutic target of neuroblastoma.

Original language	English
Pages (from-to)	3582-3586
Number of pages	5
Journal	FEBS Letters
Volume	585
Issue number	22
DOIs	https://doi.org/10.1016/j.febslet.2011.10.025
State	Published - 16 Nov 2011

Keywords

AHR
Cell differentiation
MicroRNA
Neuroblastoma
miR-124

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10.1016/j.febslet.2011.10.025

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title = "Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR",

abstract = "Neuroblastoma is the most common extracranial solid tumor in children. We investigate whether miR-124, the abundant neuronal miRNA, plays a pivotal role in neuroblastoma. Knockdown of miR-124 promotes neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis. Further miR-124 is predicted to target aryl hydrocarbon receptor (AHR) which may promote neuroblastoma cell differentiation. We validate that miR-124 may suppress the expression of AHR by targeting its 3′-UTR. These results suggest that miR-124 could serve as a potential therapeutic target of neuroblastoma.",

keywords = "AHR, Cell differentiation, MicroRNA, Neuroblastoma, miR-124",

author = "Huang, {Tsui Chin} and Chang, {Hsin Yi} and Chen, {Cheng Yu} and Wu, {Pei Yi} and Hsinyu Lee and Liao, {Yung Feng} and Hsu, {Wen Ming} and Huang, {Hsuan Cheng} and Juan, {Hsueh Fen}",

note = "Funding Information: This work was supported by National Science Council of Taiwan ( NSC 99-2621-B-002-005-MY3 and NSC 99-2621-B-010-001-MY3 ), National Health Research Institute ( NHRI-EX98-9819PI ) and the National Taiwan University Frontier and Innovative Research Program. ",

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doi = "10.1016/j.febslet.2011.10.025",

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volume = "585",

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T1 - Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR

AU - Huang, Tsui Chin

AU - Chang, Hsin Yi

AU - Chen, Cheng Yu

AU - Wu, Pei Yi

AU - Lee, Hsinyu

AU - Liao, Yung Feng

AU - Hsu, Wen Ming

AU - Huang, Hsuan Cheng

AU - Juan, Hsueh Fen

N1 - Funding Information: This work was supported by National Science Council of Taiwan ( NSC 99-2621-B-002-005-MY3 and NSC 99-2621-B-010-001-MY3 ), National Health Research Institute ( NHRI-EX98-9819PI ) and the National Taiwan University Frontier and Innovative Research Program.

PY - 2011/11/16

Y1 - 2011/11/16

N2 - Neuroblastoma is the most common extracranial solid tumor in children. We investigate whether miR-124, the abundant neuronal miRNA, plays a pivotal role in neuroblastoma. Knockdown of miR-124 promotes neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis. Further miR-124 is predicted to target aryl hydrocarbon receptor (AHR) which may promote neuroblastoma cell differentiation. We validate that miR-124 may suppress the expression of AHR by targeting its 3′-UTR. These results suggest that miR-124 could serve as a potential therapeutic target of neuroblastoma.

AB - Neuroblastoma is the most common extracranial solid tumor in children. We investigate whether miR-124, the abundant neuronal miRNA, plays a pivotal role in neuroblastoma. Knockdown of miR-124 promotes neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis. Further miR-124 is predicted to target aryl hydrocarbon receptor (AHR) which may promote neuroblastoma cell differentiation. We validate that miR-124 may suppress the expression of AHR by targeting its 3′-UTR. These results suggest that miR-124 could serve as a potential therapeutic target of neuroblastoma.

KW - AHR

KW - Cell differentiation

KW - MicroRNA

KW - Neuroblastoma

KW - miR-124

UR - http://www.scopus.com/inward/record.url?scp=80855143652&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2011.10.025

DO - 10.1016/j.febslet.2011.10.025

M3 - 期刊論文

C2 - 22024478

AN - SCOPUS:80855143652

SN - 0014-5793

VL - 585

SP - 3582

EP - 3586

JO - FEBS Letters

JF - FEBS Letters

IS - 22

ER -

Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR

Abstract

Keywords

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