Serial heart rhythm complexity changes in patients with anterior wall ST segment elevation myocardial infarction

Hung Chih Chiu; Hsi Pin Ma; Chen Lin; Men Tzung Lo; Lian Yu Lin; Cho Kai Wu; Jiun Yang Chiang; Jen Kuang Lee; Chi Sheng Hung; Tzung Dau Wang; Li Yu Daisy Liu; Yi Lwun Ho; Yen Hung Lin; Chung Kang Peng

doi:10.1038/srep43507

Serial heart rhythm complexity changes in patients with anterior wall ST segment elevation myocardial infarction

Hung Chih Chiu, Hsi Pin Ma, Chen Lin, Men Tzung Lo, Lian Yu Lin, Cho Kai Wu, Jiun Yang Chiang, Jen Kuang Lee, Chi Sheng Hung, Tzung Dau Wang, Li Yu Daisy Liu, Yi Lwun Ho, Yen Hung Lin, Chung Kang Peng

Research output: Contribution to journal › Article › peer-review

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Abstract

Heart rhythm complexity analysis has been shown to have good prognostic power in patients with cardiovascular disease. The aim of this study was to analyze serial changes in heart rhythm complexity from the acute to chronic phase of acute myocardial infarction (MI). We prospectively enrolled 27 patients with anterior wall ST segment elevation myocardial infarction (STEMI) and 42 control subjects. In detrended fluctuation analysis (DFA), the patients had significantly lower DFAα2 in the acute stage (within 72 hours) and lower DFAα1 at 3 months and 12 months after MI. In multiscale entropy (MSE) analysis, the patients had a lower slope 5 in the acute stage, which then gradually increased during the follow-up period. The areas under the MSE curves for scale 1 to 5 (area 1-5) and 6 to 20 (area 6-20) were lower throughout the chronic stage. Area 6-20 had the greatest discriminatory power to differentiate the post-MI patients (at 1 year) from the controls. In both the net reclassification improvement and integrated discrimination improvement models, MSE parameters significantly improved the discriminatory power of the linear parameters to differentiate the post-MI patients from the controls. In conclusion, the patients with STEMI had serial changes in cardiac complexity.

Original language	English
Article number	43507
Journal	Scientific Reports
Volume	7
DOIs	https://doi.org/10.1038/srep43507
State	Published - 2 Mar 2017

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title = "Serial heart rhythm complexity changes in patients with anterior wall ST segment elevation myocardial infarction",

abstract = "Heart rhythm complexity analysis has been shown to have good prognostic power in patients with cardiovascular disease. The aim of this study was to analyze serial changes in heart rhythm complexity from the acute to chronic phase of acute myocardial infarction (MI). We prospectively enrolled 27 patients with anterior wall ST segment elevation myocardial infarction (STEMI) and 42 control subjects. In detrended fluctuation analysis (DFA), the patients had significantly lower DFAα2 in the acute stage (within 72 hours) and lower DFAα1 at 3 months and 12 months after MI. In multiscale entropy (MSE) analysis, the patients had a lower slope 5 in the acute stage, which then gradually increased during the follow-up period. The areas under the MSE curves for scale 1 to 5 (area 1-5) and 6 to 20 (area 6-20) were lower throughout the chronic stage. Area 6-20 had the greatest discriminatory power to differentiate the post-MI patients (at 1 year) from the controls. In both the net reclassification improvement and integrated discrimination improvement models, MSE parameters significantly improved the discriminatory power of the linear parameters to differentiate the post-MI patients from the controls. In conclusion, the patients with STEMI had serial changes in cardiac complexity.",

author = "Chiu, {Hung Chih} and Ma, {Hsi Pin} and Chen Lin and Lo, {Men Tzung} and Lin, {Lian Yu} and Wu, {Cho Kai} and Chiang, {Jiun Yang} and Lee, {Jen Kuang} and Hung, {Chi Sheng} and Wang, {Tzung Dau} and {Daisy Liu}, {Li Yu} and Ho, {Yi Lwun} and Lin, {Yen Hung} and Peng, {Chung Kang}",

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doi = "10.1038/srep43507",

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T1 - Serial heart rhythm complexity changes in patients with anterior wall ST segment elevation myocardial infarction

AU - Chiu, Hung Chih

AU - Ma, Hsi Pin

AU - Lin, Chen

AU - Lo, Men Tzung

AU - Lin, Lian Yu

AU - Wu, Cho Kai

AU - Chiang, Jiun Yang

AU - Lee, Jen Kuang

AU - Hung, Chi Sheng

AU - Wang, Tzung Dau

AU - Daisy Liu, Li Yu

AU - Ho, Yi Lwun

AU - Lin, Yen Hung

AU - Peng, Chung Kang

PY - 2017/3/2

Y1 - 2017/3/2

N2 - Heart rhythm complexity analysis has been shown to have good prognostic power in patients with cardiovascular disease. The aim of this study was to analyze serial changes in heart rhythm complexity from the acute to chronic phase of acute myocardial infarction (MI). We prospectively enrolled 27 patients with anterior wall ST segment elevation myocardial infarction (STEMI) and 42 control subjects. In detrended fluctuation analysis (DFA), the patients had significantly lower DFAα2 in the acute stage (within 72 hours) and lower DFAα1 at 3 months and 12 months after MI. In multiscale entropy (MSE) analysis, the patients had a lower slope 5 in the acute stage, which then gradually increased during the follow-up period. The areas under the MSE curves for scale 1 to 5 (area 1-5) and 6 to 20 (area 6-20) were lower throughout the chronic stage. Area 6-20 had the greatest discriminatory power to differentiate the post-MI patients (at 1 year) from the controls. In both the net reclassification improvement and integrated discrimination improvement models, MSE parameters significantly improved the discriminatory power of the linear parameters to differentiate the post-MI patients from the controls. In conclusion, the patients with STEMI had serial changes in cardiac complexity.

AB - Heart rhythm complexity analysis has been shown to have good prognostic power in patients with cardiovascular disease. The aim of this study was to analyze serial changes in heart rhythm complexity from the acute to chronic phase of acute myocardial infarction (MI). We prospectively enrolled 27 patients with anterior wall ST segment elevation myocardial infarction (STEMI) and 42 control subjects. In detrended fluctuation analysis (DFA), the patients had significantly lower DFAα2 in the acute stage (within 72 hours) and lower DFAα1 at 3 months and 12 months after MI. In multiscale entropy (MSE) analysis, the patients had a lower slope 5 in the acute stage, which then gradually increased during the follow-up period. The areas under the MSE curves for scale 1 to 5 (area 1-5) and 6 to 20 (area 6-20) were lower throughout the chronic stage. Area 6-20 had the greatest discriminatory power to differentiate the post-MI patients (at 1 year) from the controls. In both the net reclassification improvement and integrated discrimination improvement models, MSE parameters significantly improved the discriminatory power of the linear parameters to differentiate the post-MI patients from the controls. In conclusion, the patients with STEMI had serial changes in cardiac complexity.

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Serial heart rhythm complexity changes in patients with anterior wall ST segment elevation myocardial infarction

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