Separation and Purification of Stem and Blood Cells by Porous Polymeric Membranes

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Efficient cell separation is important for the successful isolation and purification of blood cells, stem cells, and specific tissue cells. Cell separation through membrane filtration was recently reported by several researchers. Leukocyte removal filters are commercially available cell separation filters. Removal of leukocytes from the blood using these filters has successfully decreased the side effects of blood transfusions and viral infections arising from leukocytes in donor blood. Compared with other cell separation methods, membrane filtration is simple and inexpensive, and sterility is easy to maintain during the process. Recently, the authors succeeded in purifying hematopoietic stem cells from the blood by the filtration method through porous polyurethane foaming membranes having nanosegments. We also succeeded in the separation of different kinds of mesenchymal stem cells through nylon mesh filters. We have reviewed the recent membrane technology for the separation and purification of stem cells and blood cells comprehensively.

Original languageEnglish
Title of host publicationChemical and Biochemical Transformations in Membrane Systems
PublisherElsevier Inc.
Number of pages24
ISBN (Electronic)9780080932507
ISBN (Print)9780444532046
StatePublished - 9 Jul 2010


  • Biocompatibility
  • Blood
  • Cell separation
  • Filtration
  • Hematopoietic stem cells
  • Leukocytapheresis
  • Leukocyte removal filter
  • Membrane
  • Mesenchymal stem cells
  • Nanosegments


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