Selective formation of form II paracetamol through the assistance of paracetamol co-crystals as templates in a solution

Kuan Lin Yeh; Tu Lee

doi:10.1039/d1ce00034a

Selective formation of form II paracetamol through the assistance of paracetamol co-crystals as templates in a solution

Kuan Lin Yeh, Tu Lee

Department of Chemical and Materials Engineering

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Selective formation for form II instead of form I paracetamol was promoted through the assistance of structurally related packing motifs and arrangements of paracetamol co-crystals in an aqueous solution. Form II paracetamol was produced by cooling crystallization in water with either oxalic acid or maleic acid. The co-crystal lattice structures of paracetamol with oxalic acid and maleic acid were similar to the packing pattern of form II paracetamol.

Original language	English
Pages (from-to)	3940-3945
Number of pages	6
Journal	CrystEngComm
Volume	23
Issue number	22
DOIs	https://doi.org/10.1039/d1ce00034a
State	Published - 14 Jun 2021

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10.1039/d1ce00034a

Crystallization Process Design of Highly Soluble Compounds(3/3)
Lee, T. (PI)
1/08/20 → 31/07/21
Project: Research

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abstract = "Selective formation for form II instead of form I paracetamol was promoted through the assistance of structurally related packing motifs and arrangements of paracetamol co-crystals in an aqueous solution. Form II paracetamol was produced by cooling crystallization in water with either oxalic acid or maleic acid. The co-crystal lattice structures of paracetamol with oxalic acid and maleic acid were similar to the packing pattern of form II paracetamol.",

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AB - Selective formation for form II instead of form I paracetamol was promoted through the assistance of structurally related packing motifs and arrangements of paracetamol co-crystals in an aqueous solution. Form II paracetamol was produced by cooling crystallization in water with either oxalic acid or maleic acid. The co-crystal lattice structures of paracetamol with oxalic acid and maleic acid were similar to the packing pattern of form II paracetamol.

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Selective formation of form II paracetamol through the assistance of paracetamol co-crystals as templates in a solution

Abstract

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Crystallization Process Design of Highly Soluble Compounds(3/3)

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