Robustness and variability of pathways in the spontaneous synchronous bursting of clusterized cortical neuronal networks in vitro

Chen Yu Tsai, Mei Chu Chang, Lin I

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4 Scopus citations

Abstract

We experimentally demonstrate the observation of several pathways with a few tens of ms inter-cluster delay but negligible intra-cluster delay, in the spontaneous synchronous burstings (SSBs) of clusterized cortical neuronal networks in vitro through epifluorescence microscopy of Ca2+ indicator. Nearby clusters sharing the similar relative firing timings in different SSB events form a group. Switching among different SSB pathways initiated by different master groups is found. Under chemical tuning such as decreasing the mutual coupling by increasing [Mg2+] or lowering the effective firing threshold by increasing [K+], the firing sequence of each pathway remains robust, but the occurrence probability and the temporal persistence of each pathway, and the inter-cluster delay times in the firing sequences can be varied.

Original languageEnglish
Article number084803
JournalJournal of the Physical Society of Japan
Volume77
Issue number8
DOIs
StatePublished - Aug 2008

Keywords

  • Calcium indicator
  • Epifluorescence microscopy
  • Hierarchical network
  • Neuronal cluster
  • Neuronal networks
  • Robustness
  • Synchronous bursting
  • Variability

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