Reversible heart rhythm complexity impairment in patients with primary aldosteronism

Yen Hung Lin, Vin Cent Wu, Men Tzung Lo, Xue Ming Wu, Chi Sheng Hung, Kwan Dun Wu, Chen Lin, Yi Lwun Ho, Michael Stowasser, Chung Kang Peng

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20 Scopus citations


Excess aldosterone secretion in patients with primary aldosteronism (PA) impairs their cardiovascular system. Heart rhythm complexity analysis, derived from heart rate variability (HRV), is a powerful tool to quantify the complex regulatory dynamics of human physiology. We prospectively analyzed 20 patients with aldosterone producing adenoma (APA) that underwent adrenalectomy and 25 patients with essential hypertension (EH). The heart rate data were analyzed by conventional HRV and heart rhythm complexity analysis including detrended fluctuation analysis (DFA) and multiscale entropy (MSE). We found APA patients had significantly decreased DFAα2 on DFA analysis and decreased area 1-5, area 6-15, and area 6-20 on MSE analysis (all pa €‰<a €‰0.05). Area 1-5, area 6-15, area 6-20 in the MSE study correlated significantly with log-transformed renin activity and log-transformed aldosterone-renin ratio (all pa €‰<a €‰=a €‰0.01). The conventional HRV parameters were comparable between PA and EH patients. After adrenalectomy, all the altered DFA and MSE parameters improved significantly (all pa €‰<a €‰0.05). The conventional HRV parameters did not change. Our result suggested that heart rhythm complexity is impaired in APA patients and this is at least partially reversed by adrenalectomy.

Original languageEnglish
Article number11249
JournalScientific Reports
StatePublished - 18 Aug 2015


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