Retinal prostheses in degenerative retinal diseases

Tai Chi Lin, Hua Ming Chang, Chih Chien Hsu, Kuo Hsuan Hung, Yan Ting Chen, Szu Yu Chen, Shih Jen Chen

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Degenerative retinal diseases may lead to significant loss of vision. Age-related macular degeneration (AMD) and retinitis pigmentosa (RP), which eventually affect the photoreceptors, are the two most common retinal degenerative diseases. Once the photoreceptorcells are lost, there are no known effective therapies for AMD or RP. The concept of retinal prosthesis is to elicit neural activity in the remaining retinal neurons by detecting light and converting it into electrical stimuli using artificial devices. Subretinal, epiretinal, and other retinal prostheses implants are currently designed to restore functional vision in retinal degenerative diseases. In this review, we have summarized different types of retinal prostheses, implant locations, and visual outcomes. Our discussions will further elucidate the results from clinical trials, and the challenges that will need to be overcome to more efficaciously assist patients with AMD and RP in the future.

Original languageEnglish
Pages (from-to)501-505
Number of pages5
JournalJournal of the Chinese Medical Association
Volume78
Issue number9
DOIs
StatePublished - 1 Sep 2015

Keywords

  • Age-related macular degeneration
  • Epiretinal implants
  • Retinal prosthesis
  • Retinitis pigmentosa
  • Subretinal implants

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