Repeated morphological evolution through cis-regulatory changes in a pleiotropic gene

Benjamin Prud'homme, Nicolas Gompel, Antonis Rokas, Victoria A. Kassner, Thomas M. Williams, Shu Dan Yeh, John R. True, Sean B. Carroll

Research output: Contribution to journalArticlepeer-review

350 Scopus citations

Abstract

The independent evolution of morphological similarities is widespread1,2. For simple traits, such as overall body colour, repeated transitions by means of mutations in the same gene may be common3-5. However, for more complex traits, the possible genetic paths may be more numerous; the molecular mechanisms underlying their independent origins and the extent to which they are constrained to follow certain genetic paths are largely unknown. Here we show that a male wing pigmentation pattern involved in courtship display has been gained and lost multiple times in a Drosophila clade. Each of the cases we have analysed (two gains and two losses) involved regulatory changes at the pleiotropic pigmentation gene yellow. Losses involved the parallel inactivation of the same cis-regulatory element (CRE), with changes at a few nucleotides sufficient to account for the functional divergence of one element between two sibling species. Surprisingly, two independent gains of wing spots resulted from the co-option of distinct ancestral CREs. These results demonstrate how the functional diversification of the modular CREs of pleiotropic genes contributes to evolutionary novelty and the independent evolution of morphological similarities.

Original languageEnglish
Pages (from-to)1050-1053
Number of pages4
JournalNature
Volume440
Issue number7087
DOIs
StatePublished - 20 Apr 2006

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