Recovery of Active Pharmaceutical Ingredients from Unused Solid Dosage-Form Drugs

Dhanang Edy Pratama, Wen Chen Hsieh, Ahmed Elmaamoun, Hung Lin Lee, Tu Lee

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The concept of drug recycle by recovering active pharmaceutical ingredients (APIs) from unused tablets and capsules was demonstrated using acetaminophen, tetracycline HCl, and (R,S)-(±)-ibuprofen as case examples. The recovery process comprised three core unit operations: solid-liquid extraction, filtration, and crystallization. Recovery yields of 58.7 wt %, 73.1 wt %, and 67.6 wt % for acetaminophen, tetracycline HCl, and (R,S)-(±)-ibuprofen were achieved, respectively. More importantly, all of the APIs were of high purity based on high-performance liquid chromatography assay. The crystal forms of the recovered APIs were in conformity with the standards.

Original languageEnglish
Pages (from-to)29147-29157
Number of pages11
JournalACS Omega
Volume5
Issue number45
DOIs
StatePublished - 17 Nov 2020

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