Recent progress in one-pot enzymatic synthesis and regeneration of high-value cofactors

I. Son Ng; Po Hsiang Wang; Wan Wen Ting; Jiun Jang Juo

doi:10.1016/j.tibtech.2024.08.006

Recent progress in one-pot enzymatic synthesis and regeneration of high-value cofactors

I. Son Ng
, Po Hsiang Wang
, Wan Wen Ting
, Jiun Jang Juo

Graduate Institute of Environmental Engineering

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

One-pot enzymatic synthesis is flourishing in synthetic chemistry, heralding a sustainable and green era. Recent advancements enable the creation of complex enzymatic prosthetic groups and regeneration of enzymatic cofactors such as S-adenosylmethionine. The next frontier is to develop the effective and innovative cofactors for essential micronutrients, metabolic modulators, and biomedicines.

Original language	English
Pages (from-to)	270-273
Number of pages	4
Journal	Trends in Biotechnology
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/j.tibtech.2024.08.006
State	Published - Feb 2025

Keywords

S-adenosylmethionine
cell-free protein synthesis
cofactors
enzymatic
one-pot bioconversion

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10.1016/j.tibtech.2024.08.006

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abstract = "One-pot enzymatic synthesis is flourishing in synthetic chemistry, heralding a sustainable and green era. Recent advancements enable the creation of complex enzymatic prosthetic groups and regeneration of enzymatic cofactors such as S-adenosylmethionine. The next frontier is to develop the effective and innovative cofactors for essential micronutrients, metabolic modulators, and biomedicines.",

keywords = "S-adenosylmethionine, cell-free protein synthesis, cofactors, enzymatic, one-pot bioconversion",

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AU - Ng, I. Son

AU - Wang, Po Hsiang

AU - Ting, Wan Wen

AU - Juo, Jiun Jang

PY - 2025/2

Y1 - 2025/2

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AB - One-pot enzymatic synthesis is flourishing in synthetic chemistry, heralding a sustainable and green era. Recent advancements enable the creation of complex enzymatic prosthetic groups and regeneration of enzymatic cofactors such as S-adenosylmethionine. The next frontier is to develop the effective and innovative cofactors for essential micronutrients, metabolic modulators, and biomedicines.

KW - S-adenosylmethionine

KW - cell-free protein synthesis

KW - cofactors

KW - enzymatic

KW - one-pot bioconversion

UR - https://www.scopus.com/pages/publications/85202841968

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DO - 10.1016/j.tibtech.2024.08.006

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JO - Trends in Biotechnology

JF - Trends in Biotechnology

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Recent progress in one-pot enzymatic synthesis and regeneration of high-value cofactors

Abstract

Keywords

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