Recent development in nano-sized dosage forms of plant alkaloid camptothecin-derived drugs

Nguyen Van Cuong, Ming Fa Hsieh, Chun Ming Huang

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

DNA topoisomerase is one of drug targets in cancer therapy. Camptothecin is a plant alkaloid derived from the Chinese tree Camptotheca acuminate. It has been demonstrated that the plant alkaloid camptothecin (CPT) caused DNA damage by specifically targeting DNA topoisomerase, effectively devastating a broad spectrum of tumors. Although the anti-tumoral activity of CPT has been intensively studies for nearly fifty years, recent advances in drug delivery systems of CPT have considerably improved this drug's efficiency. In this review, we will summarize the current status of CPT-derived anti-cancer drugs in literatures and patents and highlight their clinical application.

Original languageEnglish
Pages (from-to)254-261
Number of pages8
JournalRecent Patents on Anti-Cancer Drug Discovery
Volume4
Issue number3
DOIs
StatePublished - 2009

Keywords

  • 9-nitrocamptothecin
  • Aminocamptothecin
  • Camptothecin
  • DNA topoisomerase I
  • Irinotecan
  • IT-101
  • Liposomal delivery
  • Nanomedicine
  • Nanoparticles
  • NK012
  • SN-38

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