Real-time monitoring DNA hybridization by guided resonant mode biosensor

Jiann Hwa Lue; Ting Jou Ding; Tsung Hsun Yang; Hsin Chun Huang; Che Lung Hsu; Jen Tsai Liu; Wen Yih Chen; Jenq Yang Chang

doi:10.1109/NEMS.2011.6017574

Real-time monitoring DNA hybridization by guided resonant mode biosensor

Jiann Hwa Lue, Ting Jou Ding, Tsung Hsun Yang, Hsin Chun Huang, Che Lung Hsu, Jen Tsai Liu, Wen Yih Chen, Jenq Yang Chang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

In this paper, a label free approach of the DNA hybridization detection by the guided-mode resonance (GMR) spectroscopy sensor is presented. The GMR biosensor can easily detect any slight variation of the DNA hybridization by the resonant wavelength peak shift. The corresponding peak wavelength shifts of the capture DNA, the target DNA and the probe DNA serially hybridized reactions from GMR are measured, respectively. Furthermore, the stability and reliability of the GMR biosensor for nucleic acid hybridization have also been examined. The result obviously reveals the feasibility of implementation of the GMR-based DNA microarray for detecting on the dynamics of DNA hybridization.

Original language	English
Title of host publication	NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems
Pages	1208-1211
Number of pages	4
DOIs	https://doi.org/10.1109/NEMS.2011.6017574
State	Published - 2011
Event	6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011 - Kaohsiung, Taiwan Duration: 20 Feb 2011 → 23 Feb 2011

Publication series

Name	NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems

Conference

Conference	6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011
Country/Territory	Taiwan
City	Kaohsiung
Period	20/02/11 → 23/02/11

Keywords

Grating
Guided-mode resonance
Soft lithography
Sol-Ge
Subwavelength

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10.1109/NEMS.2011.6017574

Cite this

Lue, J. H., Ding, T. J., Yang, T. H., Huang, H. C., Hsu, C. L., Liu, J. T., Chen, W. Y., & Chang, J. Y. (2011). Real-time monitoring DNA hybridization by guided resonant mode biosensor. In NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (pp. 1208-1211). Article 6017574 (NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems). https://doi.org/10.1109/NEMS.2011.6017574

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title = "Real-time monitoring DNA hybridization by guided resonant mode biosensor",

abstract = "In this paper, a label free approach of the DNA hybridization detection by the guided-mode resonance (GMR) spectroscopy sensor is presented. The GMR biosensor can easily detect any slight variation of the DNA hybridization by the resonant wavelength peak shift. The corresponding peak wavelength shifts of the capture DNA, the target DNA and the probe DNA serially hybridized reactions from GMR are measured, respectively. Furthermore, the stability and reliability of the GMR biosensor for nucleic acid hybridization have also been examined. The result obviously reveals the feasibility of implementation of the GMR-based DNA microarray for detecting on the dynamics of DNA hybridization.",

keywords = "Grating, Guided-mode resonance, Soft lithography, Sol-Ge, Subwavelength",

author = "Lue, {Jiann Hwa} and Ding, {Ting Jou} and Yang, {Tsung Hsun} and Huang, {Hsin Chun} and Hsu, {Che Lung} and Liu, {Jen Tsai} and Chen, {Wen Yih} and Chang, {Jenq Yang}",

year = "2011",

doi = "10.1109/NEMS.2011.6017574",

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isbn = "9781612847757",

series = "NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems",

pages = "1208--1211",

booktitle = "NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems",

note = "6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011 ; Conference date: 20-02-2011 Through 23-02-2011",

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Lue, JH, Ding, TJ, Yang, TH, Huang, HC, Hsu, CL, Liu, JT, Chen, WY & Chang, JY 2011, Real-time monitoring DNA hybridization by guided resonant mode biosensor. in NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems., 6017574, NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, pp. 1208-1211, 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011, Kaohsiung, Taiwan, 20/02/11. https://doi.org/10.1109/NEMS.2011.6017574

Real-time monitoring DNA hybridization by guided resonant mode biosensor. / Lue, Jiann Hwa; Ding, Ting Jou; Yang, Tsung Hsun et al.
NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems. 2011. p. 1208-1211 6017574 (NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Real-time monitoring DNA hybridization by guided resonant mode biosensor

AU - Lue, Jiann Hwa

AU - Ding, Ting Jou

AU - Yang, Tsung Hsun

AU - Huang, Hsin Chun

AU - Hsu, Che Lung

AU - Liu, Jen Tsai

AU - Chen, Wen Yih

AU - Chang, Jenq Yang

PY - 2011

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N2 - In this paper, a label free approach of the DNA hybridization detection by the guided-mode resonance (GMR) spectroscopy sensor is presented. The GMR biosensor can easily detect any slight variation of the DNA hybridization by the resonant wavelength peak shift. The corresponding peak wavelength shifts of the capture DNA, the target DNA and the probe DNA serially hybridized reactions from GMR are measured, respectively. Furthermore, the stability and reliability of the GMR biosensor for nucleic acid hybridization have also been examined. The result obviously reveals the feasibility of implementation of the GMR-based DNA microarray for detecting on the dynamics of DNA hybridization.

AB - In this paper, a label free approach of the DNA hybridization detection by the guided-mode resonance (GMR) spectroscopy sensor is presented. The GMR biosensor can easily detect any slight variation of the DNA hybridization by the resonant wavelength peak shift. The corresponding peak wavelength shifts of the capture DNA, the target DNA and the probe DNA serially hybridized reactions from GMR are measured, respectively. Furthermore, the stability and reliability of the GMR biosensor for nucleic acid hybridization have also been examined. The result obviously reveals the feasibility of implementation of the GMR-based DNA microarray for detecting on the dynamics of DNA hybridization.

KW - Grating

KW - Guided-mode resonance

KW - Soft lithography

KW - Sol-Ge

KW - Subwavelength

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M3 - 會議論文篇章

AN - SCOPUS:80053330973

SN - 9781612847757

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ER -

Lue JH, Ding TJ, Yang TH, Huang HC, Hsu CL, Liu JT et al. Real-time monitoring DNA hybridization by guided resonant mode biosensor. In NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems. 2011. p. 1208-1211. 6017574. (NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems). doi: 10.1109/NEMS.2011.6017574

Real-time monitoring DNA hybridization by guided resonant mode biosensor

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