Real-time monitoring DNA hybridization by guided resonant mode biosensor

Jiann Hwa Lue, Ting Jou Ding, Tsung Hsun Yang, Hsin Chun Huang, Che Lung Hsu, Jen Tsai Liu, Wen Yih Chen, Jenq Yang Chang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

In this paper, a label free approach of the DNA hybridization detection by the guided-mode resonance (GMR) spectroscopy sensor is presented. The GMR biosensor can easily detect any slight variation of the DNA hybridization by the resonant wavelength peak shift. The corresponding peak wavelength shifts of the capture DNA, the target DNA and the probe DNA serially hybridized reactions from GMR are measured, respectively. Furthermore, the stability and reliability of the GMR biosensor for nucleic acid hybridization have also been examined. The result obviously reveals the feasibility of implementation of the GMR-based DNA microarray for detecting on the dynamics of DNA hybridization.

Original languageEnglish
Title of host publicationNEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems
Pages1208-1211
Number of pages4
DOIs
StatePublished - 2011
Event6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011 - Kaohsiung, Taiwan
Duration: 20 Feb 201123 Feb 2011

Publication series

NameNEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems

Conference

Conference6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011
Country/TerritoryTaiwan
CityKaohsiung
Period20/02/1123/02/11

Keywords

  • Grating
  • Guided-mode resonance
  • Soft lithography
  • Sol-Ge
  • Subwavelength

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