Rational design and synthesis of unsaturated 2,5-dioxopiperazine derivatives as potential protein tyrosine kinase inhibitors

Wen Ren Li, Shao Zheng Peng

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

The first general method for the synthesis of a library of trifunctionalized (Z)-3-alkylidene-2,5-piperazinediones as potential protein tyrosine kinase inhibitors from commercially available amino compounds, α- keto acids and aldehydes using a novel cyclization/cleavage strategy on solid support is described.

Original languageEnglish
Pages (from-to)7373-7376
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number40
DOIs
StatePublished - 1 Oct 1998

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