Rapid screening of potential metallic glasses for biomedical applications

C. H. Lin, C. H. Huang, J. F. Chuang, J. C. Huang, J. S.C. Jang, C. H. Chen

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

This paper presents a rapid screening process to select potential titanium and zirconium based metallic glasses (MGs) for bio-material applications. Electrochemical activity of 7 MGs including 6 bulk metallic glasses and 1 thin-film deposited MG in simulation body and human serum is first inspected. A lowvoltage potential state test is also developed to simulate the cell membrane potential that the implant MGs will suffer. Results show that the MGs composed of Ti65Si15Ta10Zr10 and Ta 57Zr23Cu12Ti8 exhibit excellent electrochemical stability in both simulation body fluid and human serum. In addition, the copper content in the MGs plays an important role on the electrochemical activity. MGs with the copper content higher than 17.5% show significant electrochemical responses. The cytotoxicity of the solid MG samples and the corrosion released ions are also evaluated by an in-vitro MTT test utilizing the murine bone marrow stem cells. Results indicate that all the solid MG samples show no acute cytotoxicity yet the corrosion released ions show significant toxicity for murine bone marrow stem cells. The rapid screening process developed in the present study suggests that the Ti65Si 15Ta10Zr10 metallic glass has high potential for biomedical applications due to its good electrochemical stability and very low cytotoxicity.

Original languageEnglish
Pages (from-to)4520-4526
Number of pages7
JournalMaterials Science and Engineering C
Volume33
Issue number8
DOIs
StatePublished - 1 Dec 2013

Keywords

  • Cytotoxicity
  • Electrochemical activity
  • Metallic glasses
  • MTT test
  • Potential state

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