TY - JOUR
T1 - Psychomotor Symptoms, Cognitive Impairments, and Suicidal Thoughts after COVID-19 Infection
T2 - A Case Report and Possible Allostatic Mechanism
AU - Lin, Ying
AU - Lin, Chen
AU - Chang, Jason Hong Yi
AU - Chiang, Dai Lun
AU - Lai, Feipei
AU - Lin, Chen Ju
N1 - Publisher Copyright:
© 2024 by The Korean Geriatrics Society.
PY - 2024/9/1
Y1 - 2024/9/1
N2 - Although neuropsychiatric manifestations are common in survivors of coronavirus disease 2019 (COVID-19), the pathophysiology is not yet elucidated. Here we describe the case of a geriatric inpatient who developed post-COVID depression with psychomotor retardation, anxiety, hope-lessness, executive function problems, and suicidal ideations. The language problems and cognitive impairments coemerged with the motor problems. We propose a mechanism associated with problems in energy prediction and regulation in which the coronavirus infection, which causes neuroinflammation and viral activity in the nervous system, interferes with the reward pathway and sensory prediction process. Sigma-1 receptor agonists such as sertraline may regulate energy expenditure and, thus, be beneficial to the process. The treatment improvements in our patient included those in the autonomic nervous system, activity, and circadian rhythm.
AB - Although neuropsychiatric manifestations are common in survivors of coronavirus disease 2019 (COVID-19), the pathophysiology is not yet elucidated. Here we describe the case of a geriatric inpatient who developed post-COVID depression with psychomotor retardation, anxiety, hope-lessness, executive function problems, and suicidal ideations. The language problems and cognitive impairments coemerged with the motor problems. We propose a mechanism associated with problems in energy prediction and regulation in which the coronavirus infection, which causes neuroinflammation and viral activity in the nervous system, interferes with the reward pathway and sensory prediction process. Sigma-1 receptor agonists such as sertraline may regulate energy expenditure and, thus, be beneficial to the process. The treatment improvements in our patient included those in the autonomic nervous system, activity, and circadian rhythm.
KW - Aged
KW - Allostasis
KW - COVID brain fog
KW - COVID-19
KW - Post-acute COVID-19 syndrome
UR - http://www.scopus.com/inward/record.url?scp=85206240111&partnerID=8YFLogxK
U2 - 10.4235/agmr.24.0037
DO - 10.4235/agmr.24.0037
M3 - 期刊論文
AN - SCOPUS:85206240111
SN - 2508-4798
VL - 28
SP - 370
EP - 374
JO - Annals of Geriatric Medicine and Research
JF - Annals of Geriatric Medicine and Research
IS - 3
ER -