Protein tyrosine phosphatases and their inhibitors

Purushottam M. Dewang; Nai Mu Hsu; Shao Zheng Peng; Wen Ren Li

doi:10.2174/0929867053363504

Protein tyrosine phosphatases and their inhibitors

Purushottam M. Dewang, Nai Mu Hsu, Shao Zheng Peng, Wen Ren Li

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years.

Original language	English
Pages (from-to)	1-22
Number of pages	22
Journal	Current Medicinal Chemistry
Volume	12
Issue number	1
DOIs	https://doi.org/10.2174/0929867053363504
State	Published - 2005

Keywords

Cellular signaling
Diseases
Inhibitors
PTPs
SAR
Therapeutics/drugs

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Protein tyrosine phosphatases and their inhibitors

Abstract

Keywords

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