Protein tyrosine phosphatases and their inhibitors

Purushottam M. Dewang, Nai Mu Hsu, Shao Zheng Peng, Wen Ren Li

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years.

Original languageEnglish
Pages (from-to)1-22
Number of pages22
JournalCurrent Medicinal Chemistry
Volume12
Issue number1
DOIs
StatePublished - 2005

Keywords

  • Cellular signaling
  • Diseases
  • Inhibitors
  • PTPs
  • SAR
  • Therapeutics/drugs

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