Protein tyrosine phosphatases and their inhibitors

Yogesh S. Tingare; Purushottam M. Dewang; Nai Mu Hsu; Shao Zheng Peng; Wen Ren Li

Protein tyrosine phosphatases and their inhibitors

Yogesh S. Tingare, Purushottam M. Dewang, Nai Mu Hsu, Shao Zheng Peng, Wen Ren Li

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years. All rights reserved -

Original language	English
Pages (from-to)	371-423
Number of pages	53
Journal	Frontiers in Medicinal Chemistry
Volume	4
Issue number	1
State	Published - 2009

Keywords

Cellular signaling
Diseases
Inhibitors
PTPs
SAR
Therapeutics/drugs

Cite this

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Protein tyrosine phosphatases and their inhibitors

Abstract

Keywords

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