Protein tyrosine phosphatases and their inhibitors

Yogesh S. Tingare, Purushottam M. Dewang, Nai Mu Hsu, Shao Zheng Peng, Wen Ren Li

Research output: Contribution to journalReview articlepeer-review


Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years. All rights reserved -

Original languageEnglish
Pages (from-to)371-423
Number of pages53
JournalFrontiers in Medicinal Chemistry
Issue number1
StatePublished - 2009


  • Cellular signaling
  • Diseases
  • Inhibitors
  • PTPs
  • SAR
  • Therapeutics/drugs


Dive into the research topics of 'Protein tyrosine phosphatases and their inhibitors'. Together they form a unique fingerprint.

Cite this