Probing the fractal pattern of heartbeats in drosophila pupae by visible optical recording system

Chen Lin, Yi Chung Chang, Ya Chen Cheng, Po Jung Lai, Chien Hung Yeh, Wan Hsin Hsieh, Kun Hu, June Tai Wu, Hsiu Hsiang Lee, Men Tzung Lo, Yi Lwun Ho

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Judiciously tuning heart rates is critical for regular cardiovascular function. The fractal pattern of heartbeats-a multiscale regulation in instantaneous fluctuations-is well known for vertebrates. The most primitive heart system of the Drosophila provides a useful model to understand the evolutional origin of such a fractal pattern as well as the alterations of fractal pattern during diseased statuses. We developed a non-invasive visible optical heart rate recording system especially suitable for long-term recording by using principal component analysis (PCA) instead of fluorescence recording system to avoid the confounding effect from intense light irradiation. To deplete intracellular Ca 2+ levels, the expression of sarco-endoplasmic reticulum Ca 2+ -ATPase (SERCA) was tissue-specifically knocked down. The SERCA group shows longer heart beat intervals (Mean ± SD: 1009.7 ± 151.6 ms) as compared to the control group (545.5 ± 45.4 ms, p < 0.001). The multiscale correlation of SERCA group (scaling exponent: 0.77 ± 0.07), on the other hand, is weaker than that of the control Drosophila (scaling exponent: 0.85 ± 0.03) (p = 0.016).

Original languageEnglish
Article number31950
JournalScientific Reports
StatePublished - 18 Aug 2016


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