Preparation and hemocompatibility of surface-modified membranes

Akira Takahashi, Ryoji Umehara, Yuki Matsuoka, Satsuki Egashira, Shizue Natori, Akon Higuchi

Research output: Contribution to conferencePaperpeer-review


When blood is applied to biomaterials, there is an initial adsorption of serum proteins. This is followed by platelet adhesion and activation of coagulation pathways, leading to thrombus formation. Several surface-modified polysulfone (PSf) hollow fibers were prepared with chemical modification. In this study, the polymerization of vinylpyrrolidone (VP) acryl morpholine (ACMO), N,N'-dimethyl acylamide(DMAA) and zwitterionic monomer of N,N-dimethyl-N- methacryloxyethyl-N-(3-sulfopropyl)ammonium betaine (SPE) on the surface of the polysulfone hollow fibers is reported. Platelet adhesion and serum protein adsorption on the polysulfone membranes conjugated with SPE, VP, ACMO and DMAA polymer on the surface from human plasma are investigated.

Original languageEnglish
Number of pages1
StatePublished - 2006
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: 24 May 200626 May 2006


Conference55th SPSJ Annual Meeting


  • Hemocompatibility
  • Hollow fiber
  • Polysultone
  • Zwitter ion


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