Predictive roles of brain-derived neurotrophic factor Val66Met polymorphism on antidepressant efficacy of different forms of prefrontal brain stimulation monotherapy: A randomized, double-blind, sham-controlled study

Chih Ming Cheng; Chen Jee Hong; Hui Ching Lin; Po Jui Chu; Mu Hong Chen; Pei Chi Tu; Ya Mei Bai; Wen Han Chang; Chi Hung Juan; Wei Chen Lin; Shih Jen Tsai; Tung Ping Su; Cheng Ta Li

doi:10.1016/j.jad.2021.10.077

Predictive roles of brain-derived neurotrophic factor Val66Met polymorphism on antidepressant efficacy of different forms of prefrontal brain stimulation monotherapy: A randomized, double-blind, sham-controlled study

Chih Ming Cheng, Chen Jee Hong, Hui Ching Lin, Po Jui Chu, Mu Hong Chen, Pei Chi Tu, Ya Mei Bai, Wen Han Chang, Chi Hung Juan, Wei Chen Lin, Shih Jen Tsai, Tung Ping Su, Cheng Ta Li

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: Although repetitive transcranial magnetic stimulation (rTMS) and prolonged intermittent theta-burst stimulation (piTBS) can induce changes in synaptic plasticity, the influence of brain-derived neurotrophic factor (BDNF) genotypes on their antidepressant effects remain unknown. Hence, we investigated the BDNF polymorphism contribution to the antidepressant effect of different forms left-sided prefrontal stimulations in a randomized, sham-controlled study Methods: Seventy-five patients with medication-resistant depression were randomly assigned into three monotherapy groups: piTBS, high-frequency(HF) rTMS, or sham. The acute treatment period was two weeks. 17-item Hamilton Depression Rating scale (HDRS-17) were applied at baseline, week-1, and week-2. The primary outcome was percentage changes of HDRS-17 (%HDRS-17 changes) analyzed by generalized estimating equation (GEE) model. Results: The GEE analysis revealed a significant interaction between group, time, and BDNF genotypes effects on %HDRS-17 changes over time. In patients carrying Val homozygotes, piTBS and HF-rTMS both exhibited significantly greater %HDRS reduction than sham at week-2. In Met carriers, only piTBS showed better efficacy than sham at week-2 (piTBS vs. sham, -41.1% vs.-18.9%, p=0.004). Regarding the influence of different BDNF genotypes on antidepressant efficacy in each intervention, only HF-rTMS exhibited significantly different degrees of %HDRS-17 changes between Val homozygotes and Met carriers (-68.5% vs. -26.4%, p=0.012, respectively), but piTBS delivered the consistent efficacy regardless of the BDNF polymorphism. Conclusions: This is the first study to confirm the different impacts of BDNF genotypes on the effect of different left-sided prefrontal brain stimulation. BDNF Val66Met polymorphism may play a role in the antidepressant response of piTBS and HF-rTMS. (Trial Registration Number UMIN-CTR:UMIN000020892: Registration date: Feb.4,

Original language	English
Pages (from-to)	353-359
Number of pages	7
Journal	Journal of Affective Disorders
Volume	297
DOIs	https://doi.org/10.1016/j.jad.2021.10.077
State	Published - 15 Jan 2022

Keywords

Antidepressant efficacy
BDNF polymorphism
Prolonged intermittent theta-burst stimulation
Repetitive transcranial magnetic stimulation
Val66Met

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10.1016/j.jad.2021.10.077

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情緒的心智腦科技：結合電生理及影像人工智慧與經顱磁刺激探究精神適應症之偵測、調控與診療(1/2)
Juan, C.-H. (PI)
1/06/19 → 31/12/20
Project: Research

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Cheng, C. M., Hong, C. J., Lin, H. C., Chu, P. J., Chen, M. H., Tu, P. C., Bai, Y. M., Chang, W. H., Juan, C. H., Lin, W. C., Tsai, S. J., Su, T. P., & Li, C. T. (2022). Predictive roles of brain-derived neurotrophic factor Val66Met polymorphism on antidepressant efficacy of different forms of prefrontal brain stimulation monotherapy: A randomized, double-blind, sham-controlled study. Journal of Affective Disorders, 297, 353-359. https://doi.org/10.1016/j.jad.2021.10.077

@article{e6b07100aa5c41ce9be1a531f729a9fa,

title = "Predictive roles of brain-derived neurotrophic factor Val66Met polymorphism on antidepressant efficacy of different forms of prefrontal brain stimulation monotherapy: A randomized, double-blind, sham-controlled study",

abstract = "Background: Although repetitive transcranial magnetic stimulation (rTMS) and prolonged intermittent theta-burst stimulation (piTBS) can induce changes in synaptic plasticity, the influence of brain-derived neurotrophic factor (BDNF) genotypes on their antidepressant effects remain unknown. Hence, we investigated the BDNF polymorphism contribution to the antidepressant effect of different forms left-sided prefrontal stimulations in a randomized, sham-controlled study Methods: Seventy-five patients with medication-resistant depression were randomly assigned into three monotherapy groups: piTBS, high-frequency(HF) rTMS, or sham. The acute treatment period was two weeks. 17-item Hamilton Depression Rating scale (HDRS-17) were applied at baseline, week-1, and week-2. The primary outcome was percentage changes of HDRS-17 (%HDRS-17 changes) analyzed by generalized estimating equation (GEE) model. Results: The GEE analysis revealed a significant interaction between group, time, and BDNF genotypes effects on %HDRS-17 changes over time. In patients carrying Val homozygotes, piTBS and HF-rTMS both exhibited significantly greater %HDRS reduction than sham at week-2. In Met carriers, only piTBS showed better efficacy than sham at week-2 (piTBS vs. sham, -41.1% vs.-18.9%, p=0.004). Regarding the influence of different BDNF genotypes on antidepressant efficacy in each intervention, only HF-rTMS exhibited significantly different degrees of %HDRS-17 changes between Val homozygotes and Met carriers (-68.5% vs. -26.4%, p=0.012, respectively), but piTBS delivered the consistent efficacy regardless of the BDNF polymorphism. Conclusions: This is the first study to confirm the different impacts of BDNF genotypes on the effect of different left-sided prefrontal brain stimulation. BDNF Val66Met polymorphism may play a role in the antidepressant response of piTBS and HF-rTMS. (Trial Registration Number UMIN-CTR:UMIN000020892: Registration date: Feb.4,",

keywords = "Antidepressant efficacy, BDNF polymorphism, Prolonged intermittent theta-burst stimulation, Repetitive transcranial magnetic stimulation, Val66Met",

author = "Cheng, {Chih Ming} and Hong, {Chen Jee} and Lin, {Hui Ching} and Chu, {Po Jui} and Chen, {Mu Hong} and Tu, {Pei Chi} and Bai, {Ya Mei} and Chang, {Wen Han} and Juan, {Chi Hung} and Lin, {Wei Chen} and Tsai, {Shih Jen} and Su, {Tung Ping} and Li, {Cheng Ta}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2022",

month = jan,

day = "15",

doi = "10.1016/j.jad.2021.10.077",

language = "???core.languages.en_GB???",

volume = "297",

pages = "353--359",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

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Cheng, CM, Hong, CJ, Lin, HC, Chu, PJ, Chen, MH, Tu, PC, Bai, YM, Chang, WH, Juan, CH, Lin, WC, Tsai, SJ, Su, TP & Li, CT 2022, 'Predictive roles of brain-derived neurotrophic factor Val66Met polymorphism on antidepressant efficacy of different forms of prefrontal brain stimulation monotherapy: A randomized, double-blind, sham-controlled study', Journal of Affective Disorders, vol. 297, pp. 353-359. https://doi.org/10.1016/j.jad.2021.10.077

Predictive roles of brain-derived neurotrophic factor Val66Met polymorphism on antidepressant efficacy of different forms of prefrontal brain stimulation monotherapy: A randomized, double-blind, sham-controlled study. / Cheng, Chih Ming; Hong, Chen Jee; Lin, Hui Ching et al.
In: Journal of Affective Disorders, Vol. 297, 15.01.2022, p. 353-359.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Predictive roles of brain-derived neurotrophic factor Val66Met polymorphism on antidepressant efficacy of different forms of prefrontal brain stimulation monotherapy

T2 - A randomized, double-blind, sham-controlled study

AU - Cheng, Chih Ming

AU - Hong, Chen Jee

AU - Lin, Hui Ching

AU - Chu, Po Jui

AU - Chen, Mu Hong

AU - Tu, Pei Chi

AU - Bai, Ya Mei

AU - Chang, Wen Han

AU - Juan, Chi Hung

AU - Lin, Wei Chen

AU - Tsai, Shih Jen

AU - Su, Tung Ping

AU - Li, Cheng Ta

PY - 2022/1/15

Y1 - 2022/1/15

N2 - Background: Although repetitive transcranial magnetic stimulation (rTMS) and prolonged intermittent theta-burst stimulation (piTBS) can induce changes in synaptic plasticity, the influence of brain-derived neurotrophic factor (BDNF) genotypes on their antidepressant effects remain unknown. Hence, we investigated the BDNF polymorphism contribution to the antidepressant effect of different forms left-sided prefrontal stimulations in a randomized, sham-controlled study Methods: Seventy-five patients with medication-resistant depression were randomly assigned into three monotherapy groups: piTBS, high-frequency(HF) rTMS, or sham. The acute treatment period was two weeks. 17-item Hamilton Depression Rating scale (HDRS-17) were applied at baseline, week-1, and week-2. The primary outcome was percentage changes of HDRS-17 (%HDRS-17 changes) analyzed by generalized estimating equation (GEE) model. Results: The GEE analysis revealed a significant interaction between group, time, and BDNF genotypes effects on %HDRS-17 changes over time. In patients carrying Val homozygotes, piTBS and HF-rTMS both exhibited significantly greater %HDRS reduction than sham at week-2. In Met carriers, only piTBS showed better efficacy than sham at week-2 (piTBS vs. sham, -41.1% vs.-18.9%, p=0.004). Regarding the influence of different BDNF genotypes on antidepressant efficacy in each intervention, only HF-rTMS exhibited significantly different degrees of %HDRS-17 changes between Val homozygotes and Met carriers (-68.5% vs. -26.4%, p=0.012, respectively), but piTBS delivered the consistent efficacy regardless of the BDNF polymorphism. Conclusions: This is the first study to confirm the different impacts of BDNF genotypes on the effect of different left-sided prefrontal brain stimulation. BDNF Val66Met polymorphism may play a role in the antidepressant response of piTBS and HF-rTMS. (Trial Registration Number UMIN-CTR:UMIN000020892: Registration date: Feb.4,

AB - Background: Although repetitive transcranial magnetic stimulation (rTMS) and prolonged intermittent theta-burst stimulation (piTBS) can induce changes in synaptic plasticity, the influence of brain-derived neurotrophic factor (BDNF) genotypes on their antidepressant effects remain unknown. Hence, we investigated the BDNF polymorphism contribution to the antidepressant effect of different forms left-sided prefrontal stimulations in a randomized, sham-controlled study Methods: Seventy-five patients with medication-resistant depression were randomly assigned into three monotherapy groups: piTBS, high-frequency(HF) rTMS, or sham. The acute treatment period was two weeks. 17-item Hamilton Depression Rating scale (HDRS-17) were applied at baseline, week-1, and week-2. The primary outcome was percentage changes of HDRS-17 (%HDRS-17 changes) analyzed by generalized estimating equation (GEE) model. Results: The GEE analysis revealed a significant interaction between group, time, and BDNF genotypes effects on %HDRS-17 changes over time. In patients carrying Val homozygotes, piTBS and HF-rTMS both exhibited significantly greater %HDRS reduction than sham at week-2. In Met carriers, only piTBS showed better efficacy than sham at week-2 (piTBS vs. sham, -41.1% vs.-18.9%, p=0.004). Regarding the influence of different BDNF genotypes on antidepressant efficacy in each intervention, only HF-rTMS exhibited significantly different degrees of %HDRS-17 changes between Val homozygotes and Met carriers (-68.5% vs. -26.4%, p=0.012, respectively), but piTBS delivered the consistent efficacy regardless of the BDNF polymorphism. Conclusions: This is the first study to confirm the different impacts of BDNF genotypes on the effect of different left-sided prefrontal brain stimulation. BDNF Val66Met polymorphism may play a role in the antidepressant response of piTBS and HF-rTMS. (Trial Registration Number UMIN-CTR:UMIN000020892: Registration date: Feb.4,

KW - Antidepressant efficacy

KW - BDNF polymorphism

KW - Prolonged intermittent theta-burst stimulation

KW - Repetitive transcranial magnetic stimulation

KW - Val66Met

UR - http://www.scopus.com/inward/record.url?scp=85118349102&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2021.10.077

DO - 10.1016/j.jad.2021.10.077

M3 - 期刊論文

C2 - 34715162

AN - SCOPUS:85118349102

SN - 0165-0327

VL - 297

SP - 353

EP - 359

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -

Predictive roles of brain-derived neurotrophic factor Val66Met polymorphism on antidepressant efficacy of different forms of prefrontal brain stimulation monotherapy: A randomized, double-blind, sham-controlled study

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Keywords

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情緒的心智腦科技：結合電生理及影像人工智慧與經顱磁刺激探究精神適應症之偵測、調控與診療(1/2)

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