Predicting future prospects of aptamers in field-effect transistor biosensors

Cao An Vu, Wen Yih Chen

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Aptamers, in sensing technology, are famous for their role as receptors in versatile applications due to their high specificity and selectivity to a wide range of targets including proteins, small molecules, oligonucleotides, metal ions, viruses, and cells. The outburst of field-effect transistors provides a label-free detection and ultra-sensitive technique with significantly improved results in terms of detection of substances. However, their combination in this field is challenged by several factors. Recent advances in the discovery of aptamers and studies of Field-Effect Transistor (FET) aptasensors overcome these limitations and potentially expand the dominance of aptamers in the biosensor market.

Original languageEnglish
Article number680
JournalMolecules
Volume25
Issue number3
DOIs
StatePublished - 5 Feb 2020

Keywords

  • Aptamer
  • Bio-amplifier
  • FET aptasensor
  • Field-effect transistor
  • Small molecule
  • Structure-switching

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