Poly(Styrene Sulfonate)/Poly(Allylamine Hydrochloride) Encapsulation of TiO2 Nanoparticles Boosts Their Toxic and Repellent Activity Against Zika Virus Mosquito Vectors

Kadarkarai Murugan, Anitha Jaganathan, Rajapandian Rajaganesh, Udaiyan Suresh, Jagan Madhavan, Sengottayan Senthil-Nathan, Aruliah Rajasekar, Akon Higuchi, Suresh S. Kumar, Abdullah A. Alarfaj, Marcello Nicoletti, Riccardo Petrelli, Loredana Cappellacci, Filippo Maggi, Giovanni Benelli

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Green fabricated nanoparticles often need to be encapsulated and stabilized, to ensure uniform dispersion in the aquatic environment and relevant larvicidal activity over time. However, recent research showed that nanoencapsulation processes led to a reduction of nanoparticle larvicidal efficacy. We used an extract of Argemone mexicana to reduce TiO2 nanoparticles, which were then capped with PSS/PAH (poly(styrene sulfonate)/poly(allylamine hydrochloride)). The toxic and repellent potential of the nanoparticles were compared to elucidate their potential effects against the Zika virus vector Aedes aegypti. Nanoparticles were characterized by biophysical methods including UV–Vis, EDX and FTIR spectroscopy, SEM, TEM, XRD and DLS analyses. In larvicidal and pupicidal experiments, TiO2 nanoparticles achieved LC90 values from 41.648 (larva I), to 71.74 ppm (pupa). Nanoencapsulated TiO2 achieved LC90 values from 39.16 (I), to 69.12 ppm (pupa). In adulticidal experiments, LC90 of TiO2 nanoparticles on Ae. aegypti was 10.31 ppm, while LC90 of nanoencapsulated TiO2 was 9.54 ppm. At 10 ppm, the repellency towards Ae. aegypti was 80.43% for TiO2 nanoparticles, and 88.04% for nanoencapsulated TiO2. This research firstly highlighted the promising potential of PSS/PAH encapsulation, leading to the production of highly effective titania nanostructures, if compared to titania nanoparticles synthesized with eco-friendly routes without further stabilization.

Original languageEnglish
Pages (from-to)27-39
Number of pages13
JournalJournal of Cluster Science
Volume29
Issue number1
DOIs
StatePublished - 1 Jan 2018

Keywords

  • Aedes aegypti
  • Argemone mexicana
  • Dengue fever
  • Encapsulation
  • Repellent activity

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