Polymeric nanopillar arrays for cell traction force measurements

Chiung Wen Kuo, Jau Ye Shiu, Fan Ching Chien, Shih Min Tsai, Di Yan Chueh, Peilin Chen

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

This paper reports the development of a novel force measurement device based on polymeric nanopillar arrays. The device was fabricated by a process combining nanosphere lithography, oxygen plasma treatment, deep etching and nano-molding. Well-ordered polymeric nanopillar arrays with various diameters and aspect ratios were fabricated and used as cell culture substrates. Cell traction forces were measured by the deflection of the nanopillars. Since the location of the nanopillars can be monitored at all times, this device allows for the measurement of the evolution of adhesion forces over time.

Original languageEnglish
Pages (from-to)3152-3158
Number of pages7
JournalElectrophoresis
Volume31
Issue number18
DOIs
StatePublished - Sep 2010

Keywords

  • Focal adhesion
  • Nanopillar
  • Traction force

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