Plasmon-enhanced optical waveguide biosensors constructed with sub-wavelength gold grating

F. C. Chien, C. Y. Lin, J. N. Yih, K. L. Lee, C. W. Chang, P. K. Wei, S. J. Chen

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations


This study develops a coupled waveguide-surface plasmon resonance (CWSPR) biosensor with a sub-wavelength grating structure for the real-time analysis of biomolecular interactions. In the proposed optical metrology system, normally incident white light is coupled into the waveguide layer through the sub-wavelength grating structure thereby enhancing the wave vector which excites the surface plasmons on the metal sensing surface. The proposed CWSPR biosensor not only retains the same sensing sensitivity as that of a conventional surface plasmon resonance device, but also yields a sharper dip in the reflectivity spectrum and therefore provides an improved measurement precision. Moreover, the metrology setup overcomes the limitations of the conventional Kretschmann attenuated total reflection approach and is less sensitive to slight variations in the angle of the incident light. The experimental results confirm that the current CWSPR biosensor provides a straightforward yet powerful technique for real-time biomolecular interaction analysis.

Original languageEnglish
Title of host publicationPlasmonics
Subtitle of host publicationMetallic Nanostructures and their Optical Properties IV
StatePublished - 2006
EventPlasmonics: Metallic Nanostructures and their Optical Properties IV - San Diego, CA, United States
Duration: 13 Aug 200616 Aug 2006

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


ConferencePlasmonics: Metallic Nanostructures and their Optical Properties IV
Country/TerritoryUnited States
CitySan Diego, CA


  • Diffraction gratin
  • Optical biosensor
  • Sub-wavelength
  • Surface plasmon resonance
  • Waveguide


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