Phyto-power dietary supplement potently inhibits dimethylnitrosamine- induced liver fibrosis in rats

Ming Fen Lee, Mei Ling Tsai, Pei Pei Sun, Ling Lung Chien, An Chin Cheng, Nianhan Jia Lin Ma, Chi Tang Ho, Min Hsiung Pan

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Curcumin has been extensively studied for its therapeutic effects in a variety of disorders. Fermented soy consumption is associated with a low incidence rate of chronic diseases in many Asian countries. The aim of this study was to investigate the potential underlying mechanisms of the effect of a phyto-power dietary supplement on liver fibrosis. Sprague-Dawley rats were intraperitoneally injected with dimethylnitrosamine (DMN; 10 mg kg-1) three times a week for four consecutive weeks. A phyto-power dietary supplement (50 or 100 mg kg-1) was administered by oral gavage daily for four weeks. Liver morphology, function, and fibrotic status were examined in DMN induced hepatic fibrogenesis. However, a phyto-power dietary supplement alleviated liver damage as indicated by histopathological examination of the α-smooth muscle actin (α-SMA) and collagen I, accompanied by the concomitant reduction of transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase 2 (MMP2). These data indicate that the phyto-power dietary supplement may inhibit the TGF-β1/Smad signaling and relieve liver damage in experimental fibrosis.

Original languageEnglish
Pages (from-to)470-475
Number of pages6
JournalFood and Function
Volume4
Issue number3
DOIs
StatePublished - Mar 2013

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