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Abstract
Both human pluripotent stem cells (hPSCs) from embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have the potential ability to differentiate into many different cell types originating from all three germ layers. This review discusses physical cues from natural and synthetic biomaterials that guide the differentiation of hESCs and hiPSCs into several different lineages. We place special focus on how the hPSC differentiation fate is affected by (a) the elasticity of biomaterials used for hPSC culture, (b) the topography of biomaterials used for hPSC culture, and (c) the mechanical forces associated with biomaterials (stretching and electrical stimulation via biomaterials) used for hPSC culture.
Original language | English |
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Pages (from-to) | 8032-8058 |
Number of pages | 27 |
Journal | Journal of Materials Chemistry B |
Volume | 3 |
Issue number | 41 |
DOIs | |
State | Published - 2015 |
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Dive into the research topics of 'Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells'. Together they form a unique fingerprint.Projects
- 1 Finished
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Development of Biomaterials for Feeder-Free and Xeno-Free Culture of Human Pluripotent Stem (Es and Ips) Cells(3/3)
Akon, H. (PI)
1/08/17 → 31/07/18
Project: Research