Phase diagram determination for phospholipid/sterol membranes using deuterium NMR

Ya Wei Hsueh, Martin Zuckermann, Jenifer Thewalt

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Deuterium NMR is used to investigate the phase behavior of membranes containing ergosterol and to measure the temperature-ergosterol mole fraction phase diagram. In particular, our approach to analyzing the NMR spectra has allowed us to definitively locate and characterize the region where two liquid crystalline phases coexist. The general methodology for phase boundary determination in phospholipid/sterol membranes is presented.

Original languageEnglish
Pages (from-to)35-46
Number of pages12
JournalConcepts in Magnetic Resonance Part A: Bridging Education and Research
Volume26
Issue number1
DOIs
StatePublished - May 2005

Keywords

  • H NMR
  • Ergosterol
  • Phase diagram
  • Phosphatidylcholine

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