Periodic-net: an end-to-end data driven framework for diffuse optical imaging of breast cancer from noisy boundary data

Nazish Murad, Min Chun Pan, Ya Fen Hsu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Significance: The machine learning (ML) approach plays a critical role in assessing biomedical imaging processes especially optical imaging (OI) including segmentation, classification, and reconstruction, intending to achieve higher accuracy efficiently. Aim: This research aims to develop an end-to-end deep learning framework for diffuse optical imaging (DOI) with multiple datasets to detect breast cancer and reconstruct its optical properties in the early stages. Approach: The proposed Periodic-net is a nondestructive deep learning (DL) algorithm for the reconstruction and evaluation of inhomogeneities in an inverse model with high accuracy, while boundary measurements are calculated by solving a forward problem with sources/detectors arranged uniformly around a circular domain in various combinations, including 16 × 15, 20 × 19, and 36 × 35 boundary measurement setups. Results: The results of image reconstruction on numerical and phantom datasets demonstrate that the proposed network provides higher-quality images with a greater amount of small details, superior immunity to noise, and sharper edges with a reduction in image artifacts than other state-of-the-art competitors. Conclusions: The network is highly effective at the simultaneous reconstruction of optical properties, i.e., absorption and reduced scattering coefficients, by optimizing the imaging time without degrading inclusions localization and image quality.

Original languageEnglish
Article number026001
JournalJournal of Biomedical Optics
Issue number2
StatePublished - 1 Feb 2023


  • diffuse optical tomography
  • frequency domain
  • inverse problem
  • machine learning
  • oncology
  • optical imaging


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