Pattern formation of skin cancers: Effects of cancer proliferation and hydrodynamic interactions

Takuma Hoshino, Ming Wei Liu, Kuo An Wu, Hsuan Yi Chen, Tatsuaki Tsuruyama, Shigeyuki Komura

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Abstract

We study pattern formation of skin cancers by means of numerical simulation of a binary system consisting of cancer and healthy cells. We extend the conventional model H for macrophase separations by considering a logistic growth of cancer cells and also a mechanical friction between dermis and epidermis. Importantly, our model exhibits a microphase separation due to the proliferation of cancer cells. By numerically solving the time evolution equations of the cancer composition and its velocity, we show that the phase separation kinetics strongly depends on the cell proliferation rate as well as on the strength of hydrodynamic interactions. A steady-state diagram of cancer patterns is established in terms of these two dynamical parameters and some of the patterns correspond to clinically observed cancer patterns. Furthermore, we examine in detail the time evolution of the average composition of cancer cells and the characteristic length of the microstructures. Our results demonstrate that different sequence of cancer patterns can be obtained by changing the proliferation rate and/or hydrodynamic interactions.

Original languageEnglish
Article number032416
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume99
Issue number3
DOIs
StatePublished - 21 Mar 2019

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