Optical immuno-biochip for detection of oral cancer biomarkers with IoT platform

Hsiang Yu Lei, Zhi Zhong Wang, Yi Chun Chen, Chia Sheng Kuo, Can Hua Yang, Chen Han Huang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Oral cavity cancer is one of the most common malignancies. Development of immunoassay based biosensor for interleukin-8 (IL-8) protein is required. The miniaturization of the device is also necessary in order to provide ready-touse portable diagnostic tools (point of care diagnostic) for clinical uses. In the current study, a compact, portable and reliable biomarker detecting and analyzing system is presented. The light absorption analysis was performed by a low-cost and portable optical sensor device. We used a programmable microcontroller unit (MCU) to operate the device. A digitalto-analog converter (DAC) was used to deliver a modulating signal to LEDs, and then the modulated light excited the samples in the microfluidic detection chamber. The signals from the sample and control group were obtained by two photodetectors individually. The photodetectors were amplified and demodulated through the lock-in amplifier, and digitized by analog-to-digital converters (ADC) to the MCU. After that, the analyzed data was uploaded to the smartphone via Bluetooth. The device demonstrates a good measurement accuracy and shorter detection time compared to conventional methods.

Original languageEnglish
Title of host publicationMicrofluidics, BioMEMS, and Medical Microsystems XVIII
EditorsBonnie L. Gray, Holger Becker
PublisherSPIE
ISBN (Electronic)9781510632332
DOIs
StatePublished - 2020
EventMicrofluidics, BioMEMS, and Medical Microsystems XVIII 2020 - San Francisco, United States
Duration: 1 Feb 20204 Feb 2020

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11235
ISSN (Print)1605-7422

Conference

ConferenceMicrofluidics, BioMEMS, and Medical Microsystems XVIII 2020
Country/TerritoryUnited States
CitySan Francisco
Period1/02/204/02/20

Keywords

  • IoT
  • microfluidic
  • optical detector
  • oral cancer
  • point of care

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