Optical biosensors based on four different surface plasmon resonance modes: Sensitivity comparison

F. C. Chien, S. J. Chen

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations


Current surface plasmon resonance (SPR) modes based on the attenuated total reflection (ATR) method can broadly be categorized as: conventional SPR, long-range SPR (LRSPR), coupled plasmon-waveguide resonance (CPWR), and waveguide-coupled SPR (WCSPR). Although the features of optical biosensors are dependent upon their particular SPR mode, a common requirement for all biosensors utilized for biomolecular interaction analysis (BIA) is a high degree of sensitivity. The current paper presents a theoretical analysis and comparison of the sensitivity and resolution of these four types of SPR biosensors when employed in three of the most prevalent detection methods, namely angular interrogation, wavelength interrogation, and intensity measurement. This study develops a detailed understanding of the influences of various biosensor design parameters in order to enhance the sensitivity and detection limit capabilities of such devices.

Original languageEnglish
Pages (from-to)148-159
Number of pages12
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2004
EventPlasmonics in Biology and Medicine - San Jose, CA, United States
Duration: 26 Jan 200427 Jan 2004


  • Biomolecular interaction analysis
  • Conventional surface plasmon resonance
  • Coupled plasmon-waveguide resonance
  • Long-range surface plasmon resonance
  • Waveguide-coupled surface plasmon resonance


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