TY - JOUR
T1 - Odontogenic epithelial stem cells
T2 - Hidden sources
AU - Padma Priya, Sivan
AU - Higuchi, Akon
AU - Abu Fanas, Salem
AU - Pooi Ling, Mok
AU - Kumari Neela, Vasantha
AU - Sunil, P. M.
AU - Saraswathi, T. R.
AU - Murugan, Kadarkarai
AU - Alarfaj, Abdullah A.
AU - Munusamy, Murugan A.
AU - Kumar, Suresh
N1 - Publisher Copyright:
© 2015 USCAP, Inc All rights reserved.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - The ultimate goal of dental stem cell research is to construct a bioengineered tooth. Tooth formation occurs based on the well-organized reciprocal interaction of epithelial and mesenchymal cells. The dental mesenchymal stem cells are the best explored, but because the human odontogenic epithelium is lost after the completion of enamel formation, studies on these cells are scarce. The successful creation of a bioengineered tooth is achievable only when the odontogenic epithelium is reconstructed to produce a replica of natural enamel. This article discusses the untapped sources of odontogenic epithelial stem cells in humans, such as those present in the active dental lamina in postnatal life, in remnants of dental lamina (the gubernaculum cord), in the epithelial cell rests of Malassez, and in reduced enamel epithelium. The possible uses of these stem cells in regenerative medicine, not just for enamel formation, are discussed.
AB - The ultimate goal of dental stem cell research is to construct a bioengineered tooth. Tooth formation occurs based on the well-organized reciprocal interaction of epithelial and mesenchymal cells. The dental mesenchymal stem cells are the best explored, but because the human odontogenic epithelium is lost after the completion of enamel formation, studies on these cells are scarce. The successful creation of a bioengineered tooth is achievable only when the odontogenic epithelium is reconstructed to produce a replica of natural enamel. This article discusses the untapped sources of odontogenic epithelial stem cells in humans, such as those present in the active dental lamina in postnatal life, in remnants of dental lamina (the gubernaculum cord), in the epithelial cell rests of Malassez, and in reduced enamel epithelium. The possible uses of these stem cells in regenerative medicine, not just for enamel formation, are discussed.
UR - http://www.scopus.com/inward/record.url?scp=84948459384&partnerID=8YFLogxK
U2 - 10.1038/labinvest.2015.108
DO - 10.1038/labinvest.2015.108
M3 - 回顧評介論文
C2 - 26367485
AN - SCOPUS:84948459384
SN - 0023-6837
VL - 95
SP - 1344
EP - 1352
JO - Laboratory Investigation
JF - Laboratory Investigation
IS - 12
ER -