Nonparametric procedures for simultaneous identification of the minimum effective dose in each of several groups

Show Li Jan, Yuh Ing Chen

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

This paper considers the extension of the dose finding problem in a one-way layout setting to the case of several groups, in which the main goal is to identify the minimum effective dose (MED) of each group simultaneously. We propose two nonparametric procedures using the respective pairwise- and Helmert-type two-sample Mann-Whitney statistics, which are applied in a step-down testing scheme for identifying the MED simultaneously. The computation for the associated p-value of the identified MED vector is discussed. One numerical example is given to illustrate the proposed procedures.

Original languageEnglish
Pages (from-to)781-789
Number of pages9
JournalJournal of Biopharmaceutical Statistics
Volume14
Issue number3
DOIs
StatePublished - 2004

Keywords

  • Dose-response study
  • Multi-group problem
  • Simultaneous inference
  • Step-down testing

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