New formation of 4,5,6,7-tetrahydroisoindoles

Duen Ren Hou, Yih Dar Hsieh, Yi Wei Hsieh

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The high-yield syntheses of 4,5,6,7-tetrahydro-isoindoles from N-substituted isoindolines under palladium catalyzed hydrogenation conditions are reported. Mechanistic study with deuterated and saturated substrates show extensive H/D exchange and the essence of aromaticity in this transformation.

Original languageEnglish
Pages (from-to)5927-5929
Number of pages3
JournalTetrahedron Letters
Volume46
Issue number35
DOIs
StatePublished - 29 Aug 2005

Keywords

  • Aromaticity
  • Hydrogenation
  • Palladium
  • Pyrrole

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