Neuronal network growth: Model and experiment

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Abstract

The growth of connections in a quasi two-dimensional neuronal network in vitro is probed by the synchronized bursting frequency of the system. A model of an early stage of active search growth followed by a later stage of diffusive search mode is proposed. Our model can explain quantitatively the variation of the critical age(for synchronized firing) of the culture as a function of cell density. The later stage of growth implies a probability of connection that is exponentially decay in the mean connectivity. The biological significance of the model is discussed in the light of homeostatic feedback and plasticity.

Original languageEnglish
Pages (from-to)4111-4116
Number of pages6
JournalInternational Journal of Modern Physics B
Volume21
Issue number23-24
DOIs
StatePublished - 30 Sep 2007

Keywords

  • Networks
  • Neurons
  • Synchronized bursting

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