Neuronal Correlates of Task Irrelevant Distractions Enhance the Detection of Attention Deficit/Hyperactivity Disorder

Chun Chuan Chen, Eric Hsiao Kuang Wu, Yan Qing Chen, Ho Jung Tsai, Chia Ru Chung, Shih Ching Yeh

Research output: Contribution to journalArticlepeer-review

Abstract

Early diagnosis and treatment can reduce the symptoms of Attention Deficit/Hyperactivity Disorder (ADHD) in children, but medical diagnosis is usually delayed. Hence, it is important to increase the efficiency of early diagnosis. Previous studies used behavioral and neuronal data during GO/NOGO task to help detect ADHD and the accuracy differed considerably from 53% to 92%, depending on the employed methods and the number of electroencephalogram (EEG) channels. It remains unclear whether data from a few EEG channels can still lead to a good accuracy of detecting ADHD. Here, we hypothesize that introducing distractions into a VR-based GO/NOGO task can augment the detection of ADHD using 6-channel EEG because children with ADHD are easily distracted. Forty-nine ADHD children and 32 typically developing children were recruited. We use a clinically applicable system with EEG to record data. Statistical analysis and machine learning methods were employed to analyze the data. The behavioral results revealed significant differences in task performance when there are distractions. The presence of distractions leads to EEG changes in both groups, indicating immaturity in inhibitory control. Importantly, the distractions additionally enhanced the between-group differences in NOGO α and γ power, reflecting insufficient inhibition in different neural networks for distraction suppression in the ADHD group. Machine learning methods further confirmed that distractions enhance the detection of ADHD with an accuracy of 85.45%. In conclusion, this system can assist in fast screenings for ADHD and the findings of neuronal correlates of distractions can help design therapeutic strategies.

Original languageEnglish
Pages (from-to)1302-1310
Number of pages9
JournalIEEE Transactions on Neural Systems and Rehabilitation Engineering
Volume31
DOIs
StatePublished - 2023

Keywords

  • Attention deficit/hyperactivity disorder (ADHD)
  • continuous performance test (CPT)
  • distractions
  • electroencephalography (EEG)
  • go/no-go task
  • machine learning
  • virtual reality (VR)

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