TY - JOUR
T1 - Neural mechanisms of inhibitory response in a battlefield scenario
T2 - A simultaneous fMRI-EEG study
AU - Ko, Li Wei
AU - Shih, Yi Cheng
AU - Chikara, Rupesh Kumar
AU - Chuang, Ya Ting
AU - Chang, Erik C.
N1 - Publisher Copyright:
© 2016 Ko, Shih, Chikara, Chuang and Chang.
PY - 2016/5/2
Y1 - 2016/5/2
N2 - The stop-signal paradigm has been widely adopted as a way to parametrically quantify the response inhibition process. To evaluate inhibitory function in realistic environmental settings, the current study compared stop-signal responses in two different scenarios: One uses simple visual symbols as go and stop signals, and the other translates the typical design into a battlefield scenario (BFS) where a sniper-scope view was the background, a terrorist image was the go signal, a hostage image was the stop signal, and the task instructions were to shoot at terrorists only when hostages were not present but to refrain from shooting if hostages appeared. The BFS created a threatening environment and allowed the evaluation of how participants' inhibitory control manifest in this realistic stop-signal task. In order to investigate the participants' brain activities with both high spatial and temporal resolution, simultaneous functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) recordings were acquired. The results demonstrated that both scenarios induced increased activity in the right inferior frontal gyrus (rIFG) and presupplementary motor area (preSMA), which have been linked to response inhibition. Notably, in right temporoparietal junction (rTPJ) we found both higher blood-oxygen-level dependent (BOLD) activation and synchronization of theta-alpha activities (4-12.Hz) in the BFS than in the traditional scenario after the stop signal. The higher activation of rTPJ in the BFS may be related to morality judgments or attentional reorienting. These results provided new insights into the complex brain networks involved in inhibitory control within naturalistic environments.
AB - The stop-signal paradigm has been widely adopted as a way to parametrically quantify the response inhibition process. To evaluate inhibitory function in realistic environmental settings, the current study compared stop-signal responses in two different scenarios: One uses simple visual symbols as go and stop signals, and the other translates the typical design into a battlefield scenario (BFS) where a sniper-scope view was the background, a terrorist image was the go signal, a hostage image was the stop signal, and the task instructions were to shoot at terrorists only when hostages were not present but to refrain from shooting if hostages appeared. The BFS created a threatening environment and allowed the evaluation of how participants' inhibitory control manifest in this realistic stop-signal task. In order to investigate the participants' brain activities with both high spatial and temporal resolution, simultaneous functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) recordings were acquired. The results demonstrated that both scenarios induced increased activity in the right inferior frontal gyrus (rIFG) and presupplementary motor area (preSMA), which have been linked to response inhibition. Notably, in right temporoparietal junction (rTPJ) we found both higher blood-oxygen-level dependent (BOLD) activation and synchronization of theta-alpha activities (4-12.Hz) in the BFS than in the traditional scenario after the stop signal. The higher activation of rTPJ in the BFS may be related to morality judgments or attentional reorienting. These results provided new insights into the complex brain networks involved in inhibitory control within naturalistic environments.
KW - Electroencephalography (EEG)
KW - Function magnetic resonance imaging (fMRI)
KW - Inhibitory control
KW - Right temporoparietal junction (rTPJ)
KW - Theta-alpha band
UR - http://www.scopus.com/inward/record.url?scp=84966774782&partnerID=8YFLogxK
U2 - 10.3389/fnhum.2016.00185
DO - 10.3389/fnhum.2016.00185
M3 - 期刊論文
AN - SCOPUS:84966774782
SN - 1662-5161
VL - 10
JO - Frontiers in Human Neuroscience
JF - Frontiers in Human Neuroscience
IS - MAY2016
M1 - 185
ER -