Nanostructured silicon substrate for desorption/ionization on silicon mass spectrometry coupled with titanium oxide and zinc oxide coated magnetic nanoparticles for phosphopeptide analysis

Chia Wen Tsao, Wen Yih Chen, Chien Han Lin, Yu Che Cheng

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The use of a nanostructured silicon (nSi) substrate for desorption/ionization on silicon mass spectrometry (DIOS-MS) integrated with functionalized iron oxide magnetic nanoparticles (MNPs) for phosphopeptide mass spectrometry (MS) analysis was demonstrated for the first time. The results indicate that the use of titanium oxide (TiO2) and zinc oxide (ZnO) coated MNPs coupled with the nSi-MS technique (MNPs/nSi-MS) is a high-performance method for phosphopeptide analysis in which the nSi serves as a matrix-free DIOS-MS target substrate with high MS detection sensitivity and the MNPs selectively capture the phosphopeptide for enhanced MS detection selectivity.

Original languageEnglish
Pages (from-to)2054-2060
Number of pages7
JournalJournal of Nanoscience and Nanotechnology
Volume17
Issue number3
DOIs
StatePublished - 1 Mar 2017

Keywords

  • Desorption/ionization on silicon
  • Magnetic nanoparticle
  • Mass spectrometry
  • Nanostructured silicon
  • Phosphopeptide

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