Nanostructured silicon coupled with iron oxide magnetic nanoparticles as enhanced desorption/ionization on silicon mass spectrometry for phosphopeptide analysis

C. W. Tsao, W. Y. Chen, C. H. Lin, Y. C. Cheng

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this paper, we demonstrate using nanostructured silicon (nSi) as desorption/ionization on silicon (DIOS) substrate and coupled with functionalized ioron oxide magnetic nanoparticles (MNPs) for phosphopeptide mass spectrometry (MS) analysis. Phospholyted peptide has been successfully selectively detected by nSi incorporated with TiO2 and ZnO MNPs. Results show that MNPs coupled nSi MS technique (MNPs/nSi-MS) is a high performance approach for phosphopeptide analysis where nSi service as DIOS-MS target substrate for high sensitivity MS detection and MNPs can selectively capture the phosphopeptide for enhanced MS detection selectivity.

Original languageEnglish
Title of host publicationNSTI
Subtitle of host publicationAdvanced Materials - TechConnect Briefs 2015
EditorsBart Romanowicz, Matthew Laudon
PublisherTaylor and Francis Inc.
Pages34-38
Number of pages5
ISBN (Electronic)9781498747271
StatePublished - 2015
Event10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 18th Annual Nanotech Conference and Expo, and the 2015 National SBIR/STTR Conference - Washington, United States
Duration: 14 Jun 201517 Jun 2015

Publication series

NameNSTI: Advanced Materials - TechConnect Briefs 2015
Volume1

Conference

Conference10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 18th Annual Nanotech Conference and Expo, and the 2015 National SBIR/STTR Conference
Country/TerritoryUnited States
CityWashington
Period14/06/1517/06/15

Keywords

  • Desorption/ionization on silicon
  • Magnetic nanoparticle
  • Mass spectrometry
  • Nanostructured silicon
  • Phosphopeptide

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