Multiple resonance fiber-optic sensor with time division multiplexing for multianalyte detection

Hsing Ying Lin; Chen Han Huang; Chia Chi Huang; Yu Chia Liu; Lai Kwan Chau

doi:10.1364/OL.37.003969

Multiple resonance fiber-optic sensor with time division multiplexing for multianalyte detection

Hsing Ying Lin, Chen Han Huang, Chia Chi Huang, Yu Chia Liu, Lai Kwan Chau

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A proof-of-concept multiwindow fiber-optic sensor utilizing multiple particle plasmon resonance (PPR) of silver nanoparticles and gold nanorods separately on two unclad portions of the fiber for multianalyte detection is demonstrated. The detection is based on intensity interrogation of multiple wavelengths by a single detector. Time division multiplexing is employed to modulate the illumination of dual-wavelength LEDs to induce PPRs for simultaneous real-time and label-free monitoring of two types of biomolecular interactions. Preliminary results reveal that a refractive index resolution of 9 × 10^-6 RIU is achieved. Moreover, the measured intensities of two windows independently respond to their respective binding events. The potential of the sensor architecture with multiple sensing windows for cascaded, higher throughput, and multianalyte biochemical detection can be expected.

Original language	English
Pages (from-to)	3969-3971
Number of pages	3
Journal	Optics Letters
Volume	37
Issue number	19
DOIs	https://doi.org/10.1364/OL.37.003969
State	Published - 1 Oct 2012

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title = "Multiple resonance fiber-optic sensor with time division multiplexing for multianalyte detection",

abstract = "A proof-of-concept multiwindow fiber-optic sensor utilizing multiple particle plasmon resonance (PPR) of silver nanoparticles and gold nanorods separately on two unclad portions of the fiber for multianalyte detection is demonstrated. The detection is based on intensity interrogation of multiple wavelengths by a single detector. Time division multiplexing is employed to modulate the illumination of dual-wavelength LEDs to induce PPRs for simultaneous real-time and label-free monitoring of two types of biomolecular interactions. Preliminary results reveal that a refractive index resolution of 9 × 10-6 RIU is achieved. Moreover, the measured intensities of two windows independently respond to their respective binding events. The potential of the sensor architecture with multiple sensing windows for cascaded, higher throughput, and multianalyte biochemical detection can be expected.",

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AU - Lin, Hsing Ying

AU - Huang, Chen Han

AU - Huang, Chia Chi

AU - Liu, Yu Chia

AU - Chau, Lai Kwan

PY - 2012/10/1

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N2 - A proof-of-concept multiwindow fiber-optic sensor utilizing multiple particle plasmon resonance (PPR) of silver nanoparticles and gold nanorods separately on two unclad portions of the fiber for multianalyte detection is demonstrated. The detection is based on intensity interrogation of multiple wavelengths by a single detector. Time division multiplexing is employed to modulate the illumination of dual-wavelength LEDs to induce PPRs for simultaneous real-time and label-free monitoring of two types of biomolecular interactions. Preliminary results reveal that a refractive index resolution of 9 × 10-6 RIU is achieved. Moreover, the measured intensities of two windows independently respond to their respective binding events. The potential of the sensor architecture with multiple sensing windows for cascaded, higher throughput, and multianalyte biochemical detection can be expected.

AB - A proof-of-concept multiwindow fiber-optic sensor utilizing multiple particle plasmon resonance (PPR) of silver nanoparticles and gold nanorods separately on two unclad portions of the fiber for multianalyte detection is demonstrated. The detection is based on intensity interrogation of multiple wavelengths by a single detector. Time division multiplexing is employed to modulate the illumination of dual-wavelength LEDs to induce PPRs for simultaneous real-time and label-free monitoring of two types of biomolecular interactions. Preliminary results reveal that a refractive index resolution of 9 × 10-6 RIU is achieved. Moreover, the measured intensities of two windows independently respond to their respective binding events. The potential of the sensor architecture with multiple sensing windows for cascaded, higher throughput, and multianalyte biochemical detection can be expected.

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Multiple resonance fiber-optic sensor with time division multiplexing for multianalyte detection

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