Multiple resonance fiber-optic sensor with time division multiplexing for multianalyte detection

Hsing Ying Lin, Chen Han Huang, Chia Chi Huang, Yu Chia Liu, Lai Kwan Chau

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


A proof-of-concept multiwindow fiber-optic sensor utilizing multiple particle plasmon resonance (PPR) of silver nanoparticles and gold nanorods separately on two unclad portions of the fiber for multianalyte detection is demonstrated. The detection is based on intensity interrogation of multiple wavelengths by a single detector. Time division multiplexing is employed to modulate the illumination of dual-wavelength LEDs to induce PPRs for simultaneous real-time and label-free monitoring of two types of biomolecular interactions. Preliminary results reveal that a refractive index resolution of 9 × 10-6 RIU is achieved. Moreover, the measured intensities of two windows independently respond to their respective binding events. The potential of the sensor architecture with multiple sensing windows for cascaded, higher throughput, and multianalyte biochemical detection can be expected.

Original languageEnglish
Pages (from-to)3969-3971
Number of pages3
JournalOptics Letters
Issue number19
StatePublished - 1 Oct 2012


Dive into the research topics of 'Multiple resonance fiber-optic sensor with time division multiplexing for multianalyte detection'. Together they form a unique fingerprint.

Cite this