Mosquitocidal, Antimalarial and Antidiabetic Potential of Musa paradisiaca-Synthesized Silver Nanoparticles: In Vivo and In Vitro Approaches

Priya Anbazhagan, Kadarkarai Murugan, Anitha Jaganathan, Vasu Sujitha, Christina Mary Samidoss, Sudalaimani Jayashanthani, Pandian Amuthavalli, Akon Higuchi, Suresh Kumar, Hui Wei, Marcello Nicoletti, Angelo Canale, Giovanni Benelli

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The development of pathogens and parasites resistant to synthetic drugs has created the need for developing alternative approaches to fight vector-borne diseases. In this research, we fabricated green-synthesized silver nanoparticles (AgNP) using Musa paradisiaca stem extract as a reducing and stabilizing agent. AgNP showed plasmon resonance reduction under UV–Vis spectrophotometry, SEM and XRD highlighted that they were crystalline in nature with face centered cubic geometry. The FTIR spectrum of AgNP exhibited main peaks at 464.74, 675.61, 797.07, 1059.42, 1402.58, 1639.69, 2115.61 and 3445.75 cm−1. AgNP showed growth inhibition activity against bacteria and fungi of public health relevance. AgNP were a valuable candidate for treatment of diabetes in STZ-treated rat by normalizing glucose, galactose and insulin. AgNP were toxic against larvae and pupae of the malaria vector Anopheles stephensi, with LC50of 3.642 (I), 5.497 (II), 8.561 (III), 13.477 (IV), and 17.898 ppm (pupae), respectively. Furthermore, the antiplasmodial activity of nanoparticles was evaluated against CQ-resistant (CQ-r) and CQ-sensitive (CQ-s) strains of Plasmodium falciparum, IC50were 84.22 μg/ml (CQ-s) and 89.24 μg/ml (CQ-r), while chloroquine IC50were 86 μg/ml (CQ-s) and 91 μg/ml (CQ-r). Overall, we add knowledge on the multipurpose effectiveness of green-fabricated nanoparticles in medicine and parasitology, which can be potentially helpful to develop newer and safer antiplasmodial agents and vector control tools.

Original languageEnglish
Pages (from-to)91-107
Number of pages17
JournalJournal of Cluster Science
Issue number1
StatePublished - 1 Jan 2017


  • Anopheles stephensi
  • Diabetes
  • Malaria
  • Nanobiotechnology
  • Plasmodium falciparum


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