Monte Carlo simulations of antibody adsorption and orientation on charged surfaces

Jian Zhou; Heng Kwong Tsao; Yu Jane Sheng; Shaoyi Jiang

doi:10.1063/1.1757434

Monte Carlo simulations of antibody adsorption and orientation on charged surfaces

Jian Zhou, Heng Kwong Tsao, Yu Jane Sheng, Shaoyi Jiang

Department of Chemical and Materials Engineering

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

The adsorption and orientation of antibodies on different charged surfaces was analyzed using Monte Carlo simulations. Investigations show the effects of surface charge density, solution pH and ionic strength with different dipole moments. The orientation of the adsorbed antibody was found from the Van der Walls (VDW) and electrostatic interactions. The results show the ability to predict and control antibody orientation in the development of biosensors.

Original language	English
Pages (from-to)	1050-1057
Number of pages	8
Journal	Journal of Chemical Physics
Volume	121
Issue number	2
DOIs	https://doi.org/10.1063/1.1757434
State	Published - 8 Jul 2004

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10.1063/1.1757434

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title = "Monte Carlo simulations of antibody adsorption and orientation on charged surfaces",

abstract = "The adsorption and orientation of antibodies on different charged surfaces was analyzed using Monte Carlo simulations. Investigations show the effects of surface charge density, solution pH and ionic strength with different dipole moments. The orientation of the adsorbed antibody was found from the Van der Walls (VDW) and electrostatic interactions. The results show the ability to predict and control antibody orientation in the development of biosensors.",

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AU - Zhou, Jian

AU - Tsao, Heng Kwong

AU - Sheng, Yu Jane

AU - Jiang, Shaoyi

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N2 - The adsorption and orientation of antibodies on different charged surfaces was analyzed using Monte Carlo simulations. Investigations show the effects of surface charge density, solution pH and ionic strength with different dipole moments. The orientation of the adsorbed antibody was found from the Van der Walls (VDW) and electrostatic interactions. The results show the ability to predict and control antibody orientation in the development of biosensors.

AB - The adsorption and orientation of antibodies on different charged surfaces was analyzed using Monte Carlo simulations. Investigations show the effects of surface charge density, solution pH and ionic strength with different dipole moments. The orientation of the adsorbed antibody was found from the Van der Walls (VDW) and electrostatic interactions. The results show the ability to predict and control antibody orientation in the development of biosensors.

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M3 - 期刊論文

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JO - Journal of Chemical Physics

JF - Journal of Chemical Physics

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Monte Carlo simulations of antibody adsorption and orientation on charged surfaces

Abstract

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