Abstract
Green tea epigallocatechin-3-gallate (EGCG) has been implicated in benefits for human health by regulating diverse cellular processes, including cell growth and apoptosis. The potential of EGCG as a therapeutic for conditions such as obesity, metabolic-associated fatty liver disease, and cancer has driven ongoing research to clarify the molecular mechanisms of its influence on cellular functions. Among the effects of EGCG is modulating the expression of microRNAs (miRNAs), small RNA molecules that finely regulate various biological processes. Recent evidence suggests that the miR-143/MAPK7 or miR-let-7a/HMGA2 pathways in preadipocytes mediate EGCG-induced cell growth inhibition. This chapter summarizes the latest studies of EGCG regulation of miRNA expression, especially as it is related to human health through beneficial effects in obesity, metabolic-associated fatty liver disease, and cancer. Characterization of miRNAs under EGCG regulation and the modulatory mechanisms regulated by their target genes will support efforts to optimize the therapeutic advantages of EGCG.
| Original language | English |
|---|---|
| Title of host publication | Tea in Health and Disease Prevention |
| Publisher | Elsevier |
| Pages | 571-580 |
| Number of pages | 10 |
| ISBN (Electronic) | 9780443141584 |
| ISBN (Print) | 9780443141591 |
| DOIs | |
| State | Published - 1 Jan 2024 |
Keywords
- Cancer
- EGCG
- Fat cell
- MAFLD
- Obesity
- microRNA
