Miniaturized cortex cooling device and system for hypothermia therapy application on freely moving rat

Chih Wei Chang, Kuan Chou Hou, Lei Chun Chou, Jin Chern Chiou, Jeng Ren Duann, Yun Wen Tsai

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This paper presents a miniaturized brain cortex cooling device and system using thermoelectric (TE) cooler for hypothermia therapy application on freely moving rat. Two type of cooling electrodes including planar and micro-needle structures are fabricated and studied by EEG recording. Comparing to prior arts, our approach can be applied under freely moving behavior. The cooling temperature is designed as 2°C to avoid permanent injury in brain. Packaged planar or needle electrode with TE cooler consumes only 2×2mm2. EEG recording electrodes and thermocouple are implanted for observation as well. Simulation result shows that TE-cooler with needle type electrode behaves deeper effective cooling depth and faster cooling response in rodent cortex range (∼2mm deep). Long term EEG monitoring on freely moving rat also presents no extra side effects with continuously cooling.

Original languageEnglish
Title of host publicationIEEE SENSORS 2012 - Proceedings
DOIs
StatePublished - 2012
Event11th IEEE SENSORS 2012 Conference - Taipei, Taiwan
Duration: 28 Oct 201231 Oct 2012

Publication series

NameProceedings of IEEE Sensors

Conference

Conference11th IEEE SENSORS 2012 Conference
Country/TerritoryTaiwan
CityTaipei
Period28/10/1231/10/12

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