MicroRNA regulators of vascular pathophysiology in chronic kidney disease

Kun Lin Wu, Chien Lung Chen, Mai Huong Thi Nguyen, Jen Chieh Tsai, Sun Chong Wang, Wen Fang Chiang, Po Jen Hsiao, Jenq Shyong Chan, Ju Jung Hou, Nianhan Ma

Research output: Contribution to journalReview articlepeer-review


Coronary artery disease (CAD) is a severe comorbidity in chronic kidney disease (CKD) due to heavy calcification in the medial layer and inflamed plaques. Chronic inflammation, endothelial dysfunction and vascular calcification are major contributors that lead to artherosclerosis in CKD. The lack of specific symptoms and signs of CAD and decreased accuracy of noninvasive diagnostic tools result in delayed diagnosis leading to increased mortality. MicroRNAs (miRNAs) are post-transcriptional regulators present in various biofluids throughout the body. In the circulation, miRNAs have been reported to be encapsulated in extracellular vesicles and serve as stable messengers for crosstalk among cells. miRNAs are involved in pathophysiologic mechanisms including CAD and can potentially be extended from basic research to clinical translational practice.

Original languageEnglish
Article number117610
JournalClinica Chimica Acta
StatePublished - 1 Nov 2023


  • Chronic kidney disease
  • Coronary artery disease
  • MicroRNA


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