Microfluidic systems using localized molecular imprinting polymers for detection of nano-scale bio-molecules based on surface plasmon resonance

Gwo Bin Lee, Shean Jen Chen, Shih Chiang Huang, Fan Ching Chien, Wen Janq Chen

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

This paper reports a new microfluidic system integrated with localized molecular imprinting polymers (MIP) for detection of nano-scale bio-molecules based on surface plasmon resonance (SPR). The label-free bio-sensing method incorporates SPR biosensing and an innovative microfluidic biochip capable of transporting a specific amount of bio-samples inside multiple microchannels using micropumps to sensing regions where multiple MIP films are locally spun-coated such that highly-sensitive, high-throughput, and highly-specific bio-sensing of nano-scale bio-molecules could be achieved. The microfluidic SPR/MIP biochips have the potential to be widely used for nano bio-sensing applications. While compared to large-scale SPR techniques, the developed microfluidic system has a comparable sensitivity with less consumption of samples and can perform the sensing in an automatic format.

Original languageEnglish
Title of host publication2005 5th IEEE Conference on Nanotechnology
PublisherIEEE Computer Society
Pages841-844
Number of pages4
ISBN (Print)0780391993, 9780780391994
DOIs
StatePublished - 2005
Event2005 5th IEEE Conference on Nanotechnology - Nagoya, Japan
Duration: 11 Jul 200515 Jul 2005

Publication series

Name2005 5th IEEE Conference on Nanotechnology
Volume2

Conference

Conference2005 5th IEEE Conference on Nanotechnology
Country/TerritoryJapan
CityNagoya
Period11/07/0515/07/05

Keywords

  • Microfluidics
  • Micropumps
  • MIP
  • SPR

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