Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications

Yueh Hsia Luo, Louis W. Chang, Pinpin Lin

Research output: Contribution to journalReview articlepeer-review

192 Scopus citations

Abstract

Nanomaterials, including metal-based nanoparticles, are used for various biological and medical applications. However, metals affect immune functions in many animal species including humans. Different physical and chemical properties induce different cellular responses, such as cellular uptake and intracellular biodistribution, leading to the different immune responses. The goals of this review are to summarize and discuss the innate and adaptive immune responses triggered by metal-based nanoparticles in a variety of immune system models.

Original languageEnglish
Article number143720
JournalBioMed Research International
Volume2015
DOIs
StatePublished - 2015

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