Mechanisms of lysophosphatidic acid-mediated lymphangiogenesis in prostate cancer

Pei Yi Wu, Yueh Chien Lin, Yuan Li Huang, Wei Min Chen, Chien Chin Chen, Hsinyu Lee

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Prostate cancer (PCa) is the most common noncutaneous cancer in men worldwide. One of its major treatments is androgen deprivation therapy, but PCa frequently relapses as aggressive castration resistant local tumors and distal metastases. Hence, the development of novel agents or treatment modalities for advanced PCa is crucial. Many tumors, including PCa, first metastasize to regional lymph nodes via lymphatic vessels. Recent findings demonstrate that the bioactive lipid lysophosphatidic acid (LPA) promotes PCa progression by regulating vascular endothelial growth factor-C (VEGF-C), a critical mediator of tumor lymphangiogenesis and lymphatic metastasis. Many of the underlying molecular mechanisms of the LPA–VEGF-C axis have been described, revealing potential biomarkers and therapeutic targets that may aid in the diagnosis and treatment of advanced PCa. Herein, we review the literature that illustrates a functional role for LPA signaling in PCa progression. These discoveries may be especially applicable to anti-lymphangiogenic strategies for the prevention and therapy of metastatic PCa.

Original languageEnglish
Pages (from-to)413
Number of pages1
JournalCancers
Volume10
Issue number11
DOIs
StatePublished - Nov 2018

Keywords

  • LPA
  • LPA receptor
  • Lymphangiogenesis
  • Prostate cancer
  • VEGF-C

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