We report a study of the charmless hadronic decay of the charged B meson to the three-body final state K+K-π+. The results are based on a data sample that contains 772×106 BB; pairs collected at the ?(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. The measured inclusive branching fraction and direct CP asymmetry are (5.38±0.40±0.35)×10-6 and -0.170±0.073±0.017, respectively, where the first uncertainties are statistical and the second are systematic. The K+K- invariant mass distribution of the signal candidates shows an excess in the region below 1.5 GeV/c2, which is consistent with the previous studies from BABAR and LHCb. In addition, strong evidence of a large direct CP asymmetry is found in the low K+K- invariant-mass region.