Measurement and modeling of metoclopramide hydrochloride (anti-emetic drug) solubility in supercritical carbon dioxide

Gholamhossein Sodeifian, Chieh Ming Hsieh, Reza Derakhsheshpour, Yu Ming Chen, Fariba Razmimanesh

Research output: Contribution to journalArticlepeer-review

Abstract

Knowledge of drug solubility data in supercritical carbon dioxide (SC-CO2) is a fundamental step in producing nano and microparticles through supercritical fluid technology. In this work, for the first time, the solubility of metoclopramide hydrochloride (MCP) in SC-CO2 was measured in pressure and temperature range of 12 to 27 MPa and 308 to 338 K, respectively. The results represented a range mole fractions of 0.15 × 10-5 to 5.56 × 10-5. To expand the application of the obtained data, six semi-empirical models and three models based on the Peng-Robinson equation of state (PR + VDW, PR + WS + Wilson and PR + MHV1 + COSMOSAC) with different mixing rules and various ways to describe intermolecular interactions were investigated. Furthermore, total enthalpy, sublimation enthalpy and solvation enthalpy relevant to MCP solvating in SC-CO2 were estimated.

Original languageEnglish
Article number103876
JournalArabian Journal of Chemistry
Volume15
Issue number7
DOIs
StatePublished - Jul 2022

Keywords

  • Metoclopramide hydrochloride
  • Peng-Robinson equation of state
  • Sodeifian model
  • Solubility
  • Supercritical carbon dioxide

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